Department of Family Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthawarorot Rd., Sriphum, Muang, Chiang Mai, 50200, Thailand.
Global Health and Chronic Conditions Research Group, Chiang Mai University, Chiang Mai, 50200, Thailand.
Sci Rep. 2024 Apr 2;14(1):7783. doi: 10.1038/s41598-024-58150-3.
While it is possible to detect cognitive decline before the age of 60, and there is a report indicating that certain cognitive abilities peak in one's 30s, the evidence regarding cognitive problems in populations younger than 65 years is scarce. This study aims to (1) determine the proportion of community-dwelling adults with different cognitive status, and (2) determine the prevalence of neuropsychiatric behaviors. A population-based survey was conducted in Chiang Mai, Thailand. Individuals aged 30 to 65 were recruited and assessed for demographic data, memory complaints, cognitive performance, and neuropsychiatric symptoms using self-reported questionnaires. In a total of 539 participants, 33.95% had mild cognitive impairment (MCI), 7.05% had subjective cognitive decline (SCD), and 52.50% had neuropsychiatric symptoms. The risk of MCI increased with age, and neuropsychiatric symptoms were significantly higher in those with MCI or SCD than in those without (p < 0.001). The most common complaints were sleep problems, anxiety, and irritability. Screening for MCI in adults aged < 65 years might be useful. However, further investigation on the appropriate age to screen and the program's cost-effectiveness is suggested.
虽然在 60 岁之前就有可能检测到认知能力下降，并且有报告表明某些认知能力在 30 多岁时达到峰值，但关于 65 岁以下人群认知问题的证据还很缺乏。本研究旨在：（1）确定具有不同认知状态的社区成年人的比例，（2）确定神经精神行为的患病率。在泰国清迈进行了一项基于人群的调查。招募了 30 至 65 岁的个体，并使用自我报告问卷评估其人口统计学数据、记忆主诉、认知表现和神经精神症状。在总共 539 名参与者中，33.95%有轻度认知障碍（MCI），7.05%有主观认知下降（SCD），52.50%有神经精神症状。MCI 的风险随年龄增长而增加，并且 MCI 或 SCD 患者的神经精神症状明显高于无 MCI 或 SCD 患者（p<0.001）。最常见的主诉是睡眠问题、焦虑和易怒。对<65 岁的成年人进行 MCI 筛查可能是有用的。但是，建议进一步调查适当的筛查年龄和该计划的成本效益。
