Department of Nutrition and Food Science, University of Tabuk, Tabuk 47512, Saudi Arabia.
Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk 47512, Saudi Arabia.
J Diabetes Res. 2024 Mar 28;2024:4873544. doi: 10.1155/2024/4873544. eCollection 2024.
The production of nanoparticles enhances the bioactivity of biological molecules for drug delivery to diseased sites. This study explains how silver nanoparticle (AgNP) coating enhanced the protection effects of vanillic acid in male diabetic rats with streptozotocin- (STZ-) induced diabetes. Twenty-four rats were divided into four groups ( = 6) for this investigation. The first group (G1) is untreated, whereas diabetes was induced in the other three groups through STZ injection. Diabetic rats that were not getting therapy were included in the second group (G2, STZ-positive), whereas the other diabetic rats were divided into the third group (G3, vanillic acid-treated) and the fourth group (G4, vanillic acid-coated AgNPs treated). The treatment lasted four weeks. In G2, the induction of diabetes significantly (at = 0.05) increased in serum glucose, glycated proteins, renal indices, interleukin-6 (IL-6), K+, immunoglobulins, and lipid peroxidation, while decreased Ca++, Na+, and other antioxidants in the kidney tissue homogenate. In addition, pathological altered signs were present in the pancreas and kidneys of diabetic rats. The renal and pancreatic tissues were effectively enhanced by vanillic acid or vanillic acid-coated AgNPs, bringing them very close to their prediabetic conditions. Vanillic acid-coated AgNPs offered a stronger defense against STZ-induced diabetes and lessened the effects of hyperglycemia compared to ordinary vanillic acid. Additionally, using vanillic acid coated with silver nanoparticles greatly increased the antioxidant and antidiabetic activity and reduced inflammation when compared to using vanillic acid alone.
纳米颗粒的生产增强了生物分子的生物活性，使其能够将药物递送到病变部位。本研究解释了银纳米颗粒（AgNP）涂层如何增强香草酸在链脲佐菌素（STZ）诱导的糖尿病雄性大鼠中的保护作用。为了进行这项研究，将 24 只大鼠分为四组（每组 6 只）。第一组（G1）未经处理，而其他三组则通过 STZ 注射诱导糖尿病。未接受治疗的糖尿病大鼠被纳入第二组（G2，STZ 阳性），而其他糖尿病大鼠则被分为第三组（G3，香草酸治疗组）和第四组（G4，香草酸包裹的 AgNPs 治疗组）。治疗持续四周。在 G2 中，糖尿病的诱导显著（p<0.05）增加了血清葡萄糖、糖化蛋白、肾脏指数、白细胞介素-6（IL-6）、K+、免疫球蛋白和脂质过氧化，同时降低了肾脏组织匀浆中的 Ca++、Na+和其他抗氧化剂。此外，糖尿病大鼠的胰腺和肾脏出现了病理改变的迹象。香草酸或香草酸包裹的 AgNPs 有效地增强了肾脏和胰腺组织，使其非常接近糖尿病前期的状态。香草酸包裹的 AgNPs 提供了比普通香草酸更强的针对 STZ 诱导的糖尿病的防御能力，并减轻了高血糖的影响。此外，与单独使用香草酸相比，使用银纳米颗粒包裹的香草酸大大提高了抗氧化和抗糖尿病活性，并减轻了炎症。
