Su Shengran, Xu Zhenyuan, He Xiang, Zhang Guoyi, Wu Haijun, Gao Yalan, Ma Yueliang, Yin Chanling, Ruan Yi, Li Kan, Lin Qiang
Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310000, China.
Hangzhou Q-MAG Technology Co.,Ltd., Hangzhou, 310000, China.
Heliyon. 2024 Apr 1;10(7):e29092. doi: 10.1016/j.heliyon.2024.e29092. eCollection 2024 Apr 15.
Optically pumped magnetometers can provide functionality for bio-magnetic field detection and mapping. This has attracted widespread attention from researchers in the biomedical science field. Magnetocardiography has been proven to be an effective method for examining heart disease. Notably, vector magnetocardiography obtains more spatial information than the conventional method by only taking a component that is perpendicular to the chest surface. In this work, a spin-exchange-relaxation-free (SERF) magnetometer with a compact size of 14 mm × 25 mm × 90 mm was developed. The device has a high sensitivity of 25 fT/ . Meanwhile, in the multichannel working mode, synchronous sensor manipulation and data acquisition can be achieved through our control software without additional data acquisition boards. Since a typical SERF magnetometer only responds to dual-axis magnetic fields, two sensors are orthogonally arranged to form a vector detection channel. Our system consists of seven channels and allows 7 × 9 vector MCG mapping by scanning. High-quality heart vector signals are measured, and P peak, QRS peak, and T peak can be distinguished clearly. To better demonstrate the vectorial information, a vector scatter plot form is also provided. Through a basic bio-electric current model, it demonstrates that triaxial MCG measurements capture a richer spatial current information than traditional uniaxial MCG, offering substantial diagnostic potential for heart diseases and shedding more light on the inversion of cardiac issues.
光泵磁力计可为生物磁场检测和测绘提供功能。这已引起生物医学科学领域研究人员的广泛关注。心磁图已被证明是检查心脏病的有效方法。值得注意的是，矢量心磁图仅通过获取垂直于胸壁表面的一个分量，就能比传统方法获得更多空间信息。在这项工作中，开发了一种尺寸紧凑，为14毫米×25毫米×90毫米的无自旋交换弛豫（SERF）磁力计。该设备具有25 fT/ 的高灵敏度。同时，在多通道工作模式下，通过我们的控制软件无需额外的数据采集板即可实现同步传感器操作和数据采集。由于典型的SERF磁力计仅对双轴磁场做出响应，因此两个传感器正交排列以形成一个矢量检测通道。我们的系统由七个通道组成，通过扫描可实现7×9的矢量心磁图测绘。测量到了高质量的心脏矢量信号，并且可以清楚地分辨出P波峰、QRS波峰和T波峰。为了更好地展示矢量信息，还提供了矢量散点图形式。通过一个基本的生物电流模型，表明与传统的单轴心磁图相比，三轴心磁图测量捕获了更丰富的空间电流信息，为心脏病诊断提供了巨大潜力，并为心脏问题的反演提供了更多启示。
