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用于新酶化学的基因组挖掘

Genome Mining for New Enzyme Chemistry.

作者信息

Nguyen Dinh T, Mitchell Douglas A, van der Donk Wilfred A

机构信息

Department of Chemistry, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Howard Hughes Medical Institute at the University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

出版信息

ACS Catal. 2024 Mar 12;14(7):4536-4553. doi: 10.1021/acscatal.3c06322. eCollection 2024 Apr 5.

DOI:10.1021/acscatal.3c06322
PMID:38601780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11002830/
Abstract

A revolution in the field of biocatalysis has enabled scalable access to compounds of high societal values using enzymes. The construction of biocatalytic routes relies on the reservoir of available enzymatic transformations. A review of uncharacterized proteins predicted from genomic sequencing projects shows that a treasure trove of enzyme chemistry awaits to be uncovered. This Review highlights enzymatic transformations discovered through various genome mining methods and showcases their potential future applications in biocatalysis.

摘要

生物催化领域的一场革命使得利用酶能够规模化地获取具有高度社会价值的化合物。生物催化路线的构建依赖于可用酶促转化反应的储备。对从基因组测序项目中预测出的未表征蛋白质的综述表明，酶化学的宝库有待发掘。本综述重点介绍了通过各种基因组挖掘方法发现的酶促转化反应，并展示了它们在生物催化中潜在的未来应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/a1e2d4831574/cs3c06322_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/9270244f364f/cs3c06322_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/ddfa20b556db/cs3c06322_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/fd8c54280a24/cs3c06322_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/75c3e246c16a/cs3c06322_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/07f8075db2af/cs3c06322_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/dade2a1f44f3/cs3c06322_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/fec7db6d0405/cs3c06322_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/a1e2d4831574/cs3c06322_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/9270244f364f/cs3c06322_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/ddfa20b556db/cs3c06322_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/fd8c54280a24/cs3c06322_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/75c3e246c16a/cs3c06322_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/07f8075db2af/cs3c06322_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/dade2a1f44f3/cs3c06322_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/fec7db6d0405/cs3c06322_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6968/11002830/a1e2d4831574/cs3c06322_0008.jpg

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