前列腺素不是肠道对霍乱毒素反应的介质。
Prostaglandins are not mediators of the intestinal response to cholera toxin.
作者信息
Smith G S, Warhurst G, Tonge A, Turnberg L A
出版信息
Gut. 1985 Jul;26(7):680-2. doi: 10.1136/gut.26.7.680.
Abstract
We have determined the release of prostaglandin E2 into the lumen of closed ileal loops in the rat and have measured the capacity of the mucosa to synthesise and degrade prostaglandin E2 both in control animals and after exposure to cholera toxin or bisacodyl. Exposure to cholera toxin caused no change in any of these measurements whereas bisacodyl caused an increase in the luminal PGE2 content. We conclude that the secretion stimulated by cholera toxin is not mediated by locally produced prostaglandins.
摘要
我们已测定前列腺素E2在大鼠闭合回肠肠袢肠腔内的释放，并测量了对照动物以及暴露于霍乱毒素或比沙可啶后黏膜合成和降解前列腺素E2的能力。暴露于霍乱毒素并未使这些测量值发生任何变化，而比沙可啶则使肠腔内前列腺素E2含量增加。我们得出结论，霍乱毒素刺激的分泌并非由局部产生的前列腺素介导。
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Effect of cholera toxin on the production of eicosanoids by rat jejunum.霍乱毒素对大鼠空肠类花生酸生成的影响。
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.
本文引用的文献
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Synthesis and degradation of prostaglandin E2 in the epithelial and sub-epithelial layers of the rat intestine.大鼠肠道上皮和上皮下层中前列腺素E2的合成与降解
Biochim Biophys Acta. 1982 Dec 13;713(3):684-7. doi: 10.1016/0005-2760(82)90331-9.
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Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.前列腺素和霍乱肠毒素对肠黏膜环磷酸腺苷积累的影响。关于前列腺素在毒素作用中起关键作用的证据不足。
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