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1
Prostaglandins are not mediators of the intestinal response to cholera toxin.前列腺素不是肠道对霍乱毒素反应的介质。
Gut. 1985 Jul;26(7):680-2. doi: 10.1136/gut.26.7.680.
2
Role of prostaglandins and cAMP in the secretory effects of cholera toxin.前列腺素和环磷酸腺苷在霍乱毒素分泌作用中的角色。
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5-HT2 and 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat.5-羟色胺2型和5-羟色胺3型受体亚型介导霍乱毒素诱导的大鼠肠液分泌。
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4
Distant intestinal stimulation by cholera toxin in rat in vivo.
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Involvement of 5-hydroxytryptamine, prostaglandin E2, and cyclic adenosine monophosphate in cholera toxin-induced fluid secretion in the small intestine of the rat in vivo.5-羟色胺、前列腺素E2和环磷酸腺苷参与霍乱毒素诱导的大鼠体内小肠液体分泌过程。
Gastroenterology. 1989 Feb;96(2 Pt 1):368-76. doi: 10.1016/0016-5085(89)91560-6.
6
Synthesis and degradation of prostaglandin E2 in the epithelial and sub-epithelial layers of the rat intestine.大鼠肠道上皮和上皮下层中前列腺素E2的合成与降解
Biochim Biophys Acta. 1982 Dec 13;713(3):684-7. doi: 10.1016/0005-2760(82)90331-9.
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Interactions of intestinal mediators in the mode of action of cholera toxin.霍乱毒素作用模式中肠道介质的相互作用。
J Med Microbiol. 1994 Jul;41(1):3-9. doi: 10.1099/00222615-41-1-3.
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Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum.霍乱毒素通过大鼠空肠中环氧化酶-2的转录后激活诱导前列腺素合成。
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Prostaglandin E in cholera toxin-induced intestinal secretion. Lack of an intermediary role.前列腺素E在霍乱毒素诱导的肠道分泌中的作用。不存在中介作用。
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Effect of cholera toxin on the production of eicosanoids by rat jejunum.霍乱毒素对大鼠空肠类花生酸生成的影响。
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.

引用本文的文献

1
Effect of cholera toxin on the production of eicosanoids by rat jejunum.霍乱毒素对大鼠空肠类花生酸生成的影响。
Br J Pharmacol. 1987 Sep;92(1):149-52. doi: 10.1111/j.1476-5381.1987.tb11306.x.

本文引用的文献

1
Synthesis and degradation of prostaglandin E2 in the epithelial and sub-epithelial layers of the rat intestine.大鼠肠道上皮和上皮下层中前列腺素E2的合成与降解
Biochim Biophys Acta. 1982 Dec 13;713(3):684-7. doi: 10.1016/0005-2760(82)90331-9.
2
Cholera toxin activation of adenylate cyclase. Roles of nucleoside triphosphates and a macromolecular factor in the ADP ribosylation of the GTP-dependent regulatory component.霍乱毒素对腺苷酸环化酶的激活作用。核苷三磷酸和一种大分子因子在依赖鸟苷三磷酸的调节成分的ADP核糖基化中的作用。
J Biol Chem. 1980 Feb 25;255(4):1252-8.
3
Cholera and prostaglandins.霍乱与前列腺素。
Nature. 1971 Jun 25;231(5304):536. doi: 10.1038/231536a0.
4
Interaction of Vibrio cholerae enterotoxin with cell membranes.霍乱弧菌肠毒素与细胞膜的相互作用。
Biochemistry. 1973 Aug 28;12(18):3547-58. doi: 10.1021/bi00742a031.
5
Prevention of cholera-induced intestinal secretion in the cat by aspirin.阿司匹林对猫霍乱诱导的肠道分泌的预防作用。
Nature. 1972 Aug 4;238(5362):273-4. doi: 10.1038/238273a0.
6
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.大鼠体内抗炎剂对霍乱肠毒素的拮抗作用。
Nature. 1972 Jan 21;235(5334):163-5. doi: 10.1038/235163a0.
7
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin.前列腺素和霍乱肠毒素对肠黏膜环磷酸腺苷积累的影响。关于前列腺素在毒素作用中起关键作用的证据不足。
J Clin Invest. 1974 Mar;53(3):941-9. doi: 10.1172/JCI107635.
8
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.霍乱肠毒素和前列腺素对肠黏膜腺苷酸环化酶的刺激作用。
J Clin Invest. 1971 Jun;50(6):1218-30. doi: 10.1172/JCI106599.
9
Effects of crude and pure cholera toxin on prostaglandin.
Prostaglandins. 1975 Jul;10(1):117-27. doi: 10.1016/0090-6980(75)90098-2.
10
PGE-mediated laxative effect of diphenolic laxatives.二酚类泻药的前列腺素E介导的缓泻作用。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Dec;305(3):241-6. doi: 10.1007/BF00498817.

前列腺素不是肠道对霍乱毒素反应的介质。

Prostaglandins are not mediators of the intestinal response to cholera toxin.

作者信息

Smith G S, Warhurst G, Tonge A, Turnberg L A

出版信息

Gut. 1985 Jul;26(7):680-2. doi: 10.1136/gut.26.7.680.

DOI:10.1136/gut.26.7.680
PMID:3860458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433008/
Abstract

We have determined the release of prostaglandin E2 into the lumen of closed ileal loops in the rat and have measured the capacity of the mucosa to synthesise and degrade prostaglandin E2 both in control animals and after exposure to cholera toxin or bisacodyl. Exposure to cholera toxin caused no change in any of these measurements whereas bisacodyl caused an increase in the luminal PGE2 content. We conclude that the secretion stimulated by cholera toxin is not mediated by locally produced prostaglandins.

摘要

我们已测定前列腺素E2在大鼠闭合回肠肠袢肠腔内的释放，并测量了对照动物以及暴露于霍乱毒素或比沙可啶后黏膜合成和降解前列腺素E2的能力。暴露于霍乱毒素并未使这些测量值发生任何变化，而比沙可啶则使肠腔内前列腺素E2含量增加。我们得出结论，霍乱毒素刺激的分泌并非由局部产生的前列腺素介导。