Lacy E R
Scand J Gastroenterol Suppl. 1985;110:63-72. doi: 10.3109/00365528509095834.
The luminal gastric mucosa of anesthetised rats was uniformly exposed to 70% ethanol for 30-45 seconds. Ninety-six per cent of the superficial epithelium was immediately destroyed. The mucosa was allowed to heal for 60 minutes, during which time 85% of the superficial mucosa had re-epithelialised. A thick gelatinous layer of necrotic cells and mucosal exudate formed over the restituted epithelium. To determine whether the mucosa could withstand a second ethanol insult, the same stomachs were re-exposed to 70% ethanol for 30-45 seconds and fixed for quantitative light microscopy. Significant damage to the newly formed epithelium was observed only when the gelatinous layer was first removed and then followed by a second ethanol insult. This resulted in uniform superficial damage to 92% of the mucosal surface with accompanying vascular stasis.
将麻醉大鼠的胃腔黏膜均匀暴露于70%乙醇中30 - 45秒。96%的表层上皮立即被破坏。让黏膜愈合60分钟，在此期间85%的表层黏膜重新上皮化。在再生上皮上形成了一层由坏死细胞和黏膜渗出物组成的厚厚的凝胶状层。为了确定黏膜是否能承受第二次乙醇损伤，将相同的胃再次暴露于70%乙醇中30 - 45秒，然后固定用于定量光学显微镜检查。仅当首先去除凝胶状层，然后进行第二次乙醇损伤时，才观察到对新形成上皮的显著损伤。这导致92%的黏膜表面出现均匀的表层损伤，并伴有血管淤滞。
