Thangapazham Rajesh L, Sharma Anuj, Maheshwari Radha K
Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Adv Exp Med Biol. 2007;595:343-57. doi: 10.1007/978-0-387-46401-5_15.
In recent years, considerable interest has been focused on curcumin a compound, isolated from turmeric. Curcumin is used as a coloring, flavoring agent and has been traditionally used in medicine and cuisine in India. The varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. This chapter reviews the data on the use of curcumin for the chemoprevention and treatment of various skin diseases like scleroderma, psoriasis and skin cancer. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor-KB inhibition. Curcumin treatment also reduced wound-healing time, improved collagen deposition and increased fibroblast and vascular density in wounds thereby enhancing both normal and impaired wound-healing. Curcumin has also been shown to have beneficial effect as a proangiogenic agent in wound-healing by inducing transforming growth factor-beta, which induces both angiogenesis and accumulation of extracellular matrix, which continues through the remodeling phase of wound repair. These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases.
近年来，人们对姜黄素（一种从姜黄中分离出的化合物）给予了极大关注。姜黄素用作色素、调味剂，在印度传统上用于医药和烹饪。姜黄素具有多种生物学特性，即使高剂量给药也无毒，这使得探索其在各种疾病如皮肤、结肠、十二指肠、胰腺、乳腺肿瘤及其他皮肤病中的应用具有吸引力。本章综述了姜黄素用于化学预防和治疗各种皮肤病如硬皮病、银屑病和皮肤癌的数据。姜黄素通过淬灭自由基和抑制核因子-κB来减轻炎症，从而保护皮肤。姜黄素治疗还缩短了伤口愈合时间，改善了胶原蛋白沉积，增加了伤口中的成纤维细胞和血管密度，从而增强正常和受损的伤口愈合。姜黄素还被证明作为一种促血管生成剂在伤口愈合中具有有益作用，它可诱导转化生长因子-β，该因子诱导血管生成和细胞外基质的积累，并持续贯穿伤口修复的重塑阶段。这些研究表明了姜黄素的有益作用以及该化合物作为一种有效无毒治疗皮肤病药物的开发潜力。
