McFarlin Brian K, Venable Adam S, Carpenter Katie C, Henning Andrea L, Ogenstad Stephan
Applied Physiology Laboratory, Department of KHPR, University of North Texas, Denton, TX, United States.
Department of Biological Sciences, University of North Texas, Denton, TX, United States.
Front Physiol. 2017 Oct 20;8:786. doi: 10.3389/fphys.2017.00786. eCollection 2017.
Exercise and physical labor in extreme environmental conditions causes transient decreases in immune cell and cytokine concentrations, likely increasing the susceptibility to opportunistic infection. Baker's yeast beta glucan (BYBG) has been previously demonstrated to be an effective countermeasure in athletes, but its effectiveness in individuals of average fitness under similar physical stress is unknown. The purpose of this study was to determine if 10 days of oral supplementation with BYBG could modify previously observed suppression of monocytes, T cells, circulating and whole blood LPS-stimulated cytokines due to strenuous exercise. Venous blood samples were collected from 109 healthy volunteers prior to, immediately after, 2 and 4 h post-exercise. Monocyte and T cell concentration, cell-surface receptor expression and serum and LPS-stimulated cytokines were assessed. BYBG significantly ( < 0.05) altered total and classic monocyte concentration and expression of CD38, CD80, CD86, TLR2, and TLR4 on monocyte subsets. BYBG also significantly increased CD4+ and CD8+ T cell concentration and the exercise response of CCR7+/CD45RA- central memory (T) cells. Likewise, BYBG significantly ( < 0.05) altered serum IFN-γ and IL-2, and LPS-stimulated IFN-γ, IL-2, IL-4, and IL-7. Taken together these data support the hypothesis that oral BYBG supplementation modulates the expected exercise response for individuals of average fitness. This may result in a decrease in susceptibility to opportunistic infections after strenuous exercise.
在极端环境条件下进行运动和体力劳动会导致免疫细胞和细胞因子浓度短暂下降，可能增加机会性感染的易感性。贝克酵母β-葡聚糖（BYBG）此前已被证明对运动员是一种有效的应对措施，但在类似身体压力下，其对普通健康水平个体的有效性尚不清楚。本研究的目的是确定口服BYBG 10天是否可以改变先前观察到的因剧烈运动导致的单核细胞、T细胞、循环和全血中脂多糖刺激的细胞因子的抑制作用。在运动前、运动后即刻、运动后2小时和4小时从109名健康志愿者采集静脉血样本。评估单核细胞和T细胞浓度、细胞表面受体表达以及血清和脂多糖刺激的细胞因子。BYBG显著（<0.05）改变了总单核细胞和经典单核细胞浓度以及单核细胞亚群上CD38、CD80、CD86、TLR2和TLR4的表达。BYBG还显著增加了CD4 +和CD8 + T细胞浓度以及CCR7 + / CD45RA - 中央记忆（T）细胞的运动反应。同样，BYBG显著（<0.05）改变了血清IFN-γ和IL-2，以及脂多糖刺激的IFN-γ、IL-2、IL-4和IL-7。综合这些数据支持以下假设：口服BYBG补充剂可调节普通健康水平个体预期的运动反应。这可能会降低剧烈运动后机会性感染的易感性。
