心血管磁共振健康心脏联盟参考范围。

Cardiovascular Magnetic Resonance Reference Ranges From the Healthy Hearts Consortium.

机构信息

William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom.

出版信息

JACC Cardiovasc Imaging. 2024 Jul;17(7):746-762. doi: 10.1016/j.jcmg.2024.01.009. Epub 2024 Apr 10.

DOI:10.1016/j.jcmg.2024.01.009

PMID:38613554

Abstract

BACKGROUND

The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care.

OBJECTIVES

This paper provides age-, sex-, and ethnicity-specific CMR reference ranges for atrial and ventricular metrics from the Healthy Hearts Consortium, an international collaborative comprising 9,088 CMR studies from verified healthy individuals, covering the complete adult age spectrum across both sexes, and with the highest ethnic diversity reported to date.

METHODS

CMR studies were analyzed using certified software with batch processing capability (cvi42, version 5.14 prototype, Circle Cardiovascular Imaging) by 2 expert readers. Three segmentation methods (smooth, papillary, anatomic) were used to contour the endocardial and epicardial borders of the ventricles and atria from long- and short-axis cine series. Clinically established ventricular and atrial metrics were extracted and stratified by age, sex, and ethnicity. Variations by segmentation method, scanner vendor, and magnet strength were examined. Reference ranges are reported as 95% prediction intervals.

RESULTS

The sample included 4,452 (49.0%) men and 4,636 (51.0%) women with average age of 61.1 ± 12.9 years (range: 18-83 years). Among these, 7,424 (81.7%) were from White, 510 (5.6%) South Asian, 478 (5.3%) mixed/other, 341 (3.7%) Black, and 335 (3.7%) Chinese ethnicities. Images were acquired using 1.5-T (n = 8,779; 96.6%) and 3.0-T (n = 309; 3.4%) scanners from Siemens (n = 8,299; 91.3%), Philips (n = 498; 5.5%), and GE (n = 291, 3.2%).

CONCLUSIONS

This work represents a resource with healthy CMR-derived volumetric reference ranges ready for clinical implementation.

摘要

背景

缺乏基于人群的心血管磁共振（CMR）参考范围是临床护理的主要缺陷。

目的

本研究提供了来自健康心脏联盟（Healthy Hearts Consortium）的基于年龄、性别和种族的心房和心室参数的 CMR 参考范围，该联盟是一个国际合作组织，包括 9088 项来自经证实的健康个体的 CMR 研究，涵盖了整个成年性别范围，并且具有迄今为止报告的最高种族多样性。

方法

使用具有批量处理能力的认证软件（cvi42，版本 5.14 原型，Circle Cardiovascular Imaging）由 2 名专家读者对 CMR 研究进行分析。使用 3 种分割方法（平滑、乳突、解剖）从长轴和短轴电影系列中对心室和心房的内心和心外膜边界进行轮廓描绘。提取并按年龄、性别和种族对临床确定的心室和心房参数进行分层。检查了分割方法、扫描仪供应商和磁体强度的变化。参考范围报告为 95%预测区间。

结果

样本包括 4452 名（49.0%）男性和 4636 名（51.0%）女性，平均年龄为 61.1±12.9 岁（范围：18-83 岁）。其中，7424 名（81.7%）来自白人，510 名（5.6%）来自南亚，478 名（5.3%）来自混合/其他，341 名（3.7%）来自黑人，335 名（3.7%）来自中国人。图像采集使用 1.5-T（n=8779；96.6%）和 3.0-T（n=309；3.4%）扫描仪，来自西门子（n=8299；91.3%）、飞利浦（n=498；5.5%）和通用电气（n=291；3.2%）。