Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Prim Care Diabetes. 2024 Jun;18(3):277-283. doi: 10.1016/j.pcd.2024.03.007. Epub 2024 Apr 16.
Studies have shown that fasting during Ramadan has different effects on circulating levels of several biochemical markers. This study aims to conduct a comprehensive evaluation of studies related to the effect of fasting in the holy month of Ramadan on lipid profile, uric acid, and HbA1c in CKD patients. Studies were systematically searched and collected from three databases (PubMed, Scopus, and Web of Science). After screening, the quality and risk of bias assessment of the selected articles were evaluated. Study heterogeneity was assessed using the Cochrane test and I² statistic. In case of any heterogeneity random effects model with the inverse-variance method was applied. All analyses were performed using STATA software version 16. Four observational studies were included in this study. The results of this meta-analysis were that cholesterol (Weighted mean differences (WMD):0.21 with 95% CI:-0.09-0.51 (P-value=:0.18)), LDL (WMD:0.06 with 95% CI -0.24-0.36 (P-value:0.69)), triglyceride (WMD:0.05 with 95% CI:-0.25-0.35 (P-value:0.73)) had not-significant increase. Uric acid (WMD: -0.11 with 95% CI: -0.42-0.21 (P-value:0.51)) and HbA1c (WMD: -0.22 with 95% CI: -0.79-0.36 (P-value: 0.46)) show a non-significant decrease. The results of the analyses did not report significant changes in the lipid profile, uric acid, and HbA1c in CKD patients after Ramadan fasting.
研究表明，在斋月禁食会对几种生化标志物的循环水平产生不同的影响。本研究旨在对与斋月禁食对慢性肾脏病患者血脂谱、尿酸和 HbA1c 的影响相关的研究进行综合评估。从三个数据库（PubMed、Scopus 和 Web of Science）系统地搜索和收集研究。筛选后，对入选文章的质量和偏倚风险进行评估。使用 Cochrane 检验和 I²统计评估研究异质性。如果存在任何异质性，则采用随机效应模型和逆方差法。所有分析均使用 STATA 软件版本 16 进行。本研究纳入了四项观察性研究。这项荟萃分析的结果表明，胆固醇（加权均数差异（WMD）：0.21，95%置信区间（CI）：-0.09-0.51（P 值：0.18））、LDL（WMD：0.06，95%CI：-0.24-0.36（P 值：0.69））、甘油三酯（WMD：0.05，95%CI：-0.25-0.35（P 值：0.73））没有显著增加。尿酸（WMD：-0.11，95%CI：-0.42-0.21（P 值：0.51））和 HbA1c（WMD：-0.22，95%CI：-0.79-0.36（P 值：0.46））显示出非显著下降。分析结果未报告慢性肾脏病患者在斋月禁食后血脂谱、尿酸和 HbA1c 没有显著变化。
