致癌基因c-erbA1定位于17号染色体上急性早幼粒细胞白血病断点的紧邻近端位置。
Localization of the oncogene c-erbA1 immediately proximal to the acute promyelocytic leukaemia breakpoint on chromosome 17.
作者信息
Sheer D, Sheppard D M, le Beau M, Rowley J D, San Roman C, Solomon E
出版信息
Ann Hum Genet. 1985 Jul;49(3):167-71. doi: 10.1111/j.1469-1809.1985.tb01690.x.
Using in situ hybridization, c-erbA1 has been mapped immediately distal to the translocation breakpoint on chromosome 17 in fibroblasts with a karyotype 46,XX, t(15;17)(q22;q11). Previous work has shown that c-erbA1 is proximal to the translocation breakpoint on chromosome 17 in the t(15;17)(q22;q12-21) in acute promyelocytic leukaemia. The oncogene can therefore be localized to the region of chromosome 17 between the breakpoints in 17q11 and 17q12-21.
运用原位杂交技术，在核型为46,XX,t(15;17)(q22;q11)的成纤维细胞中，已将c-erbA1定位在17号染色体易位断点的紧邻远端位置。先前的研究表明，在急性早幼粒细胞白血病的t(15;17)(q22;q12 - 21)中，c-erbA1位于17号染色体易位断点的近端。因此，该癌基因可定位于17号染色体上17q11和17q12 - 21断点之间的区域。
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