Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Department of Operative Dentistry, RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras Al-Khaimah, United Arab Emirates.
Int Dent J. 2024 Oct;74(5):901-909. doi: 10.1016/j.identj.2024.04.002. Epub 2024 Apr 24.
In recent years, the field of regenerative dentistry has garnered considerable attention for its focus on restoring and renewing damaged dental tissue. This narrative review explores the potential of bone morphogenetic protein 7 (BMP7) and its diverse applications in the regeneration of dental tissue. Recently, significant efforts have been made to understand BMP7's role in advancing regenerative dentistry. Amongst the various signalling molecules investigated for their regenerative capabilities, BMP7 emerges as a pivotal candidate, demonstrating the ability to stimulate the regeneration of dental pulp, periodontal, craniofacial, and alveolar bone tissues for dental implant placement. Whilst BMP7 exhibits significant promise as a therapeutic agent in regenerative dentistry, further research and clinical trials are necessary to fully unlock its potential and optimise its clinical effectiveness in addressing diverse dental and craniofacial conditions. This review highlights BMP7's substantial potential and emphasises the ongoing need for continued research to effectively harness its clinical utility in diverse dental and craniofacial contexts.
近年来，再生牙科领域因其专注于修复和更新受损的牙齿组织而备受关注。本综述探讨了骨形态发生蛋白 7（BMP7）在牙齿组织再生中的潜在应用。最近，人们做出了巨大努力来理解 BMP7 在推进再生牙科方面的作用。在研究的各种具有再生能力的信号分子中，BMP7 作为一个关键候选物脱颖而出，它显示出刺激牙髓、牙周、颅面和牙槽骨组织再生的能力，以用于牙种植体的放置。虽然 BMP7 作为再生牙科中的一种治疗剂具有显著的前景，但仍需要进一步的研究和临床试验来充分挖掘其潜力，并优化其在解决各种牙齿和颅面疾病方面的临床效果。本综述强调了 BMP7 的巨大潜力，并强调了持续研究的必要性，以有效地利用其在各种牙齿和颅面背景下的临床实用性。
