Maeda Chihiro, Tsuruta Fuminori
Master's and Doctoral Program in Biology, Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Ibaraki, Japan.
Master's and Doctoral Programs in Biology, Institute of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Ibaraki, Japan.
Int J Mol Sci. 2024 Apr 18;25(8):4443. doi: 10.3390/ijms25084443.
Brain aging causes a wide variety of changes at the molecular and cellular levels, leading to the decline of cognitive functions and increased vulnerability to neurodegenerative disorders. The research aimed at understanding the aging of the brain has made much progress in recent decades. Technological innovations such as single-cell RNA-sequencing (scRNA-seq), proteomic analyses, and spatial transcriptomic analyses have facilitated the research on the dynamic changes occurring within neurons, glia, and other cells along with their impacts on intercellular communication during aging. In this review, we introduce recent trends of how neurons and glia change during aging and discuss the impact on the brain microenvironment such as the blood-brain barrier (BBB).
大脑衰老在分子和细胞水平上会引发各种各样的变化，导致认知功能衰退，并增加患神经退行性疾病的易感性。近几十年来，旨在了解大脑衰老的研究取得了很大进展。诸如单细胞RNA测序（scRNA-seq）、蛋白质组分析和空间转录组分析等技术创新，推动了对神经元、神经胶质细胞和其他细胞在衰老过程中发生的动态变化及其对细胞间通讯影响的研究。在这篇综述中，我们介绍了神经元和神经胶质细胞在衰老过程中的变化趋势，并讨论了其对血脑屏障（BBB）等脑微环境的影响。
