Nakamura Takashi, Fujikawa Hirohisa, Ikeda Hirotake, Mizuma Satoshi
Department of Internal Medicine, Suwa Central Hospital, Nagano, JPN.
Center for General Medicine Education, School of Medicine, Keio University, Tokyo, JPN.
Cureus. 2025 Mar 16;17(3):e80649. doi: 10.7759/cureus.80649. eCollection 2025 Mar.
Histamine intolerance is a common disorder associated with an impaired histamine metabolism. It should be considered in individuals with sporadic or repeated anaphylaxis-like symptoms after seafood consumption. We encountered a 26-year-old male patient who experienced recurrent episodes of anaphylaxis-like symptoms after ingesting seafood. A detailed history-taking and a histamine 50-skin-prick test confirmed the diagnosis of histamine intolerance. In addition, a low-histamine diet and prophylactic antihistamine medication did not result in symptom recurrence. Proper management of histamine intolerance can improve the individual's quality of life.
组胺不耐受是一种与组胺代谢受损相关的常见病症。对于食用海鲜后出现散发性或反复性类过敏症状的个体，应考虑此病。我们遇到一名26岁男性患者，他在食用海鲜后反复出现类过敏症状。详细的病史采集和组胺50皮肤点刺试验确诊为组胺不耐受。此外，低组胺饮食和预防性抗组胺药物治疗并未导致症状复发。对组胺不耐受进行恰当管理可改善个体生活质量。
