Histamine intolerance is a common disorder associated with an impaired histamine metabolism. It should be considered in individuals with sporadic or repeated anaphylaxis-like symptoms after seafood consumption. We encountered a 26-year-old male patient who experienced recurrent episodes of anaphylaxis-like symptoms after ingesting seafood. A detailed history-taking and a histamine 50-skin-prick test confirmed the diagnosis of histamine intolerance. In addition, a low-histamine diet and prophylactic antihistamine medication did not result in symptom recurrence. Proper management of histamine intolerance can improve the individual's quality of life.