State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101 Beijing, China.
Development. 2024 Apr 15;151(8). doi: 10.1242/dev.202033. Epub 2024 Apr 30.
Mammalian spermatogenesis, probably the most complex of all cellular developmental processes, is an ideal model both for studying the specific mechanism of gametogenesis and for understanding the basic rules governing all developmental processes, as it entails both cell type-specific and housekeeping molecular processes. Spermatogenesis can be viewed as a mission with many tasks to accomplish, and its success is genetically programmed and ensured by the collaboration of a large number of genes. Here, I present an overview of mammalian spermatogenesis and the mechanisms underlying each step in the process, covering the cellular and molecular activities that occur at each developmental stage and emphasizing their gene regulation in light of recent studies.
哺乳动物的精子发生过程，可能是所有细胞发育过程中最复杂的，它既是研究配子发生的特定机制的理想模型，也是理解所有发育过程基本规律的理想模型，因为它既需要细胞类型特异性分子过程，也需要管家分子过程。精子发生可以被看作是一项具有许多任务要完成的使命，其成功是由大量基因的协同作用遗传编程和保证的。在这里，我概述了哺乳动物的精子发生过程以及该过程中每个步骤的机制，涵盖了每个发育阶段发生的细胞和分子活动，并根据最近的研究强调了它们的基因调控。
