Centro de Investigación de Enfermedades Tropicales, Universidad Autónoma de Guerrero, Acapulco, Guerrero, C.P. 39640, México.
División de Investigación, Hospital Juárez de México, Ciudad de Mexico, 07760, México.
BMC Infect Dis. 2024 May 2;24(1):463. doi: 10.1186/s12879-024-09341-w.
The use of temephos, the most common intervention for the chemical control of Aedes aegypti over the last half century, has disappointing results in control of the infection. The footprint of Aedes and the diseases it carries have spread relentlessly despite massive volumes of temephos. Recent advances in community participation show this might be more effective and sustainable for the control of the dengue vector.
Using data from the Camino Verde cluster randomized controlled trial, a compartmental mathematical model examines the dynamics of dengue infection with different levels of community participation, taking account of gender of respondent and exposure to temephos.
Simulation of dengue endemicity showed community participation affected the basic reproductive number of infected people. The greatest short-term effect, in terms of people infected with the virus, was the combination of temephos intervention and community participation. There was no evidence of a protective effect of temephos 220 days after the onset of the spread of dengue.
Male responses about community participation did not significantly affect modelled numbers of infected people and infectious mosquitoes. Our model suggests that, in the long term, community participation alone may have the best results. Adding temephos to community participation does not improve the effect of community participation alone.
在过去半个世纪中，使用倍硫磷（一种最常用于控制埃及伊蚊的化学干预措施）控制登革热感染的效果并不理想。尽管使用了大量的倍硫磷，但埃及伊蚊及其携带的疾病的传播却仍在无情地蔓延。最近社区参与方面的进展表明，对于控制登革热传播媒介而言，这种方法可能更加有效和可持续。
利用来自 Camino Verde 整群随机对照试验的数据，采用房室数学模型，考察了不同程度的社区参与度以及对倍硫磷暴露情况下的登革热感染动力学。
登革热流行情况的模拟表明，社区参与度影响了受感染者的基本繁殖数。就感染病毒的人数而言，短期内，倍硫磷干预与社区参与相结合的效果最佳。在登革热传播开始后 220 天，没有证据表明倍硫磷具有保护作用。
男性对社区参与的反应并没有显著影响模型中受感染人群和传染性蚊子的数量。我们的模型表明，从长远来看，单独的社区参与可能会产生最佳效果。在社区参与的基础上添加倍硫磷并不能提高社区参与的效果。
