Morales-Pérez Arcadio, Nava-Aguilera Elizabeth, Legorreta-Soberanis José, Cortés-Guzmán Antonio Juan, Balanzar-Martínez Alejandro, Harris Eva, Coloma Josefina, Alvarado-Castro Víctor M, Bonilla-Leon Mónica Violeta, Morales-Nava Liliana, Ledogar Robert J, Cockcroft Anne, Andersson Neil
Centro de Investigación de Enfermedades Tropicales (CIET), Universidad Autónoma de Guerrero, Acapulco, Guerrero, Mexico.
Departamento de Prevención y Control de Enfermedades Transmisibles por Vector, Servicios Estatales de Salud, Chilpancingo, Guerrero, Mexico.
BMC Public Health. 2017 May 30;17(Suppl 1):433. doi: 10.1186/s12889-017-4302-z.
In the Mexican state of Guerrero, some households place fish in water storage containers to prevent the development of mosquito larvae. Studies have shown that larvivorous fish reduce larva count in household water containers, but there is a lack of evidence about whether the use of fish is associated with a reduction in dengue virus infection. We used data from the follow up survey of the Camino Verde cluster randomised controlled trial of community mobilisation to reduce dengue risk to study this association.
The survey in 2012, among 90 clusters in the three coastal regions of Guerrero State, included a questionnaire to 10,864 households about socio-demographic factors and self-reported cases of dengue illness in the previous year. Paired saliva samples provided serological evidence of recent dengue infection among 4856 children aged 3-9 years. An entomological survey in the same households looked for larvae and pupae of Aedes aegypti and recorded presence of fish and temephos in water containers. We examined associations with the two outcomes of recent dengue infection and reported dengue illness in bivariate analysis and then multivariate analysis using generalized linear mixed modelling.
Some 17% (1730/10,111) of households had fish in their water containers. The presence of fish was associated with lower levels of recent dengue virus infection in children aged 3-9 years (OR 0.64; 95% CI 0.45-0.91), as was living in a rural area (OR 0.57; 95% CI 0.45-0.71), and being aged 3-5 years (OR 0.65; 95% CI 0.51-0.83). Factors associated with lower likelihood of self-reported dengue illness were: the presence of fish (OR 0.79; 95% CI 0.64-0.97), and living in a rural area (OR 0.74; 95% CI 0.65-0.84). Factors associated with higher likelihood of self-reported dengue illness were: higher education level of the household head (OR 1.28; 95% CI 1.07-1.52), living in a household with five people or less (OR 1.33; 95% CI 1.16-1.52) and household use of insecticide anti-mosquito products (OR 1.68; 95% CI 1.47-1.92).
Our study suggests that fish in water containers may reduce the risk of dengue virus infection and dengue illness. This could be a useful part of interventions to control the Aedes aegypti vector.
在墨西哥格雷罗州，一些家庭会在储水容器中放置鱼类，以防止蚊虫幼虫滋生。研究表明，食蚊鱼可减少家庭储水容器中的幼虫数量，但缺乏关于使用鱼类是否与登革热病毒感染减少相关的证据。我们利用“绿径”社区动员减少登革热风险整群随机对照试验的随访调查数据来研究这种关联。
2012年在格雷罗州三个沿海地区的90个群组中进行的调查，包括向10864户家庭发放问卷，询问社会人口学因素以及上一年自我报告的登革热病例。配对唾液样本为4856名3至9岁儿童近期登革热感染提供了血清学证据。在同一家庭中进行的昆虫学调查寻找埃及伊蚊的幼虫和蛹，并记录储水容器中鱼类和杀螟硫磷的存在情况。我们在双变量分析中研究了与近期登革热感染和报告的登革热疾病这两个结果的关联，然后使用广义线性混合模型进行多变量分析。
约17%（1730/10111）的家庭在储水容器中有鱼。鱼类的存在与3至9岁儿童近期登革热病毒感染水平较低相关（比值比0.64；95%置信区间0.45 - 0.91），居住在农村地区（比值比0.57；95%置信区间0.45 - 0.71）以及年龄在3至5岁（比值比0.65；95%置信区间0.51 - 0.83）也与之相关。与自我报告登革热疾病可能性较低相关的因素有：有鱼（比值比0.79；95%置信区间0.64 - 0.97）以及居住在农村地区（比值比0.74；95%置信区间0.65 - 0.84）。与自我报告登革热疾病可能性较高相关的因素有：户主教育水平较高（比值比1.28；95%置信区间1.07 - 1.52），居住在五人及以下家庭（比值比1.33；95%置信区间1.16 - 1.52）以及家庭使用杀虫剂防蚊产品（比值比1.68；95%置信区间1.47 - 1.92）。
我们的研究表明，储水容器中的鱼类可能会降低登革热病毒感染和登革热疾病的风险。这可能是控制埃及伊蚊传播媒介干预措施的一个有用部分。
