用于活性硫物种的偕二硫醇基前体。
Geminal-dithiol-based precursors for reactive sulfur species.
作者信息
Xu Shi, Ramush Geat, Yang Iris J, Das Eshani, Shieh Meg, Xian Ming
机构信息
Department of Chemistry, Brown University, Providence, Rhode Island, 02912, USA.
出版信息
Chem Commun (Camb). 2024 May 23;60(43):5606-5609. doi: 10.1039/d4cc01003e.
Caged -dithiols have been developed as the donors of reactive sulfur species (RSS), but the chemistry of free -dithiols as RSS donors has not been well understood. Herein, we report the study of a free -dithiol, 1,3-diphenylpropane-2,2-dithiol, as the precursor for several RSS. It releases HS under physiological conditions and can be converted to a mono--nitrosothiol, which serves as a NO donor. Furthermore, it can be converted to 3,3-dibenzyldithiirane, which is an active sulfur transfer reagent and can induce -persulfidation.
笼状二硫醇已被开发作为活性硫物种（RSS）的供体，但游离二硫醇作为RSS供体的化学性质尚未得到充分理解。在此，我们报道了对游离二硫醇1,3 - 二苯基丙烷 - 2,2 - 二硫醇作为几种RSS前体的研究。它在生理条件下释放HS，并且可以转化为一种亚硝基硫醇，作为NO供体。此外，它可以转化为3,3 - 二苄基二硫杂环丙烷，这是一种活性硫转移试剂，可诱导过硫化作用。
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