不同关节受累模式的强直性脊柱炎中的HLA - DR4
HLA-DR4 in ankylosing spondylitis with different patterns of joint involvement.
作者信息
Miehle W, Schattenkirchner M, Albert D, Bunge M
出版信息
Ann Rheum Dis. 1985 Jan;44(1):39-44. doi: 10.1136/ard.44.1.39.
Abstract
Fifty patients with ankylosing spondylitis (AS) confined to the spine and sacroiliac joints were compared with 50 cases of AS complicated by various patterns of non-axial joint involvement. Radiological and clinical features were evaluated and HLA-DR4 typing was carried out. This antigen was found in 16% of 200 normal individuals in 18% of patients suffering from exclusively axial AS, and in 54% of patients with additional purely peripheral joint involvement (wrist, finger, ankle, toe). The possibility that HLA-DR4 represents a non-specific marker for peripheral arthritis in patients with ankylosing spondylitis is discussed.
摘要
将50例局限于脊柱和骶髂关节的强直性脊柱炎（AS）患者与50例合并各种非轴性关节受累模式的AS患者进行比较。评估了放射学和临床特征，并进行了HLA - DR4分型。在200名正常个体中有16%发现该抗原，在仅患有轴性AS的患者中有18%发现该抗原，而在伴有单纯外周关节（腕关节、手指关节、踝关节、足趾关节）受累的患者中有54%发现该抗原。文中讨论了HLA - DR4代表强直性脊柱炎患者外周关节炎非特异性标志物的可能性。
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