Gomes José, Grunau Alexander, Lawrence Adrien K, Eberl Leo, Gademann Karl
University of Basel, Department of Chemistry, St. Johanns-Ring 19, CH-4056 Basel.
Chimia (Aarau). 2013;67(4):275-8. doi: 10.2533/chimia.2013.275.
Bioactive surfaces that can prevent bacterial infections are of great interest since device-related infections represent an emerging and major threat to our health-care system. For that purpose, dopamine and its derivatives have been shown to provide an exceptionally facile method for the immobilization of bioactive compounds on metal oxide surfaces through an operationally simple dip-and-rinse procedure. Based on this method, three different coating strategies for the assembly of antifouling, antibacterial, and quorum sensing modulating surfaces have been established. The anachelin chromophore and nitro-dopamine proved to be very suitable anchoring moieties as they possess better oxidative stability and binding efficiency compared to dopamine itself. Furthermore, adsorbed bioactive hybrids were shown to be stable and recycling of the surfaces could be achieved. These examples clearly demonstrate the efficiency of this approach for the production of active surfaces, such as in biomedical devices.
由于与设备相关的感染对我们的医疗系统构成了新出现的重大威胁，因此能够预防细菌感染的生物活性表面备受关注。为此，多巴胺及其衍生物已被证明可通过操作简单的浸洗程序，为在金属氧化物表面固定生物活性化合物提供一种极为简便的方法。基于此方法，已建立了三种不同的涂层策略，用于组装防污、抗菌和群体感应调节表面。与多巴胺本身相比，anachelin发色团和硝基多巴胺被证明是非常合适的锚定基团，因为它们具有更好的氧化稳定性和结合效率。此外，吸附的生物活性杂化物显示出稳定性，并且表面可以实现循环利用。这些例子清楚地证明了这种方法在生产活性表面（如生物医学设备中的表面）方面的效率。
