Viela Felipe, Navarro-Baena Iván, Jacobo-Martín Alejandra, Hernández Jaime J, Boyano-Escalera Marta, Osorio Manuel R, Rodríguez Isabel
Madrid Institute for Advanced Studies in Nanoscience (IMDEA Nanoscience) C/Faraday 9, Ciudad Universitaria de Cantoblanco Madrid 28049 Spain
RSC Adv. 2018 Jun 20;8(40):22606-22616. doi: 10.1039/c8ra03403f. eCollection 2018 Jun 19.
Nanotechnology provides a new design paradigm for alternative antibacterial strategies in the fight against drug-resistant bacteria. In this paper, the enhanced bactericidal action of moth-eye nanocomposite surfaces with a collaborative nanoparticle functional and topography structural mode of action is reported. The moth-eye nanocomposite surfaces are fabricated in combined processing steps of nanoparticle coating and surface nanoimprinting enabling the production of safer-by-design nanoparticle based antibacterial materials whereby the nanoparticle load is minimized whilst bactericidal efficiency is improved. The broad antibacterial activity of the nanocomposite moth-eye topographies is demonstrated against Gram-positive and Gram-negative and as model bacteria. The antibacterial performance of the moth-eye nanocomposite topographies is notably improved over that of the neat moth-eye surfaces with bacteria inhibition efficiencies up to 90%. Concurrently, the moth-eye nanocomposite topographies show a non-cytotoxic behaviour allowing for the normal attachment and proliferation of human keratinocytes.
纳米技术为对抗耐药细菌的替代抗菌策略提供了一种新的设计范式。本文报道了具有协同纳米颗粒功能和形貌结构作用模式的蛾眼纳米复合表面增强的杀菌作用。蛾眼纳米复合表面是通过纳米颗粒涂层和表面纳米压印的组合加工步骤制造的，能够生产基于纳米颗粒的设计更安全的抗菌材料，从而在提高杀菌效率的同时将纳米颗粒负载降至最低。以革兰氏阳性菌和革兰氏阴性菌作为模式细菌，证明了纳米复合蛾眼形貌具有广泛的抗菌活性。蛾眼纳米复合形貌的抗菌性能比纯蛾眼表面有显著提高，细菌抑制效率高达90%。同时，蛾眼纳米复合形貌表现出无细胞毒性的行为，允许人类角质形成细胞正常附着和增殖。
