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展望个性化医学的未来:数字孪生的作用和现实。

Envisioning the Future of Personalized Medicine: Role and Realities of Digital Twins.

机构信息

Department of Epidemiology and Public Health, Foch Hospital, Suresnes, France.

出版信息

J Med Internet Res. 2024 May 13;26:e50204. doi: 10.2196/50204.

Abstract

Digital twins have emerged as a groundbreaking concept in personalized medicine, offering immense potential to transform health care delivery and improve patient outcomes. It is important to highlight the impact of digital twins on personalized medicine across the understanding of patient health, risk assessment, clinical trials and drug development, and patient monitoring. By mirroring individual health profiles, digital twins offer unparalleled insights into patient-specific conditions, enabling more accurate risk assessments and tailored interventions. However, their application extends beyond clinical benefits, prompting significant ethical debates over data privacy, consent, and potential biases in health care. The rapid evolution of this technology necessitates a careful balancing act between innovation and ethical responsibility. As the field of personalized medicine continues to evolve, digital twins hold tremendous promise in transforming health care delivery and revolutionizing patient care. While challenges exist, the continued development and integration of digital twins hold the potential to revolutionize personalized medicine, ushering in an era of tailored treatments and improved patient well-being. Digital twins can assist in recognizing trends and indicators that might signal the presence of diseases or forecast the likelihood of developing specific medical conditions, along with the progression of such diseases. Nevertheless, the use of human digital twins gives rise to ethical dilemmas related to informed consent, data ownership, and the potential for discrimination based on health profiles. There is a critical need for robust guidelines and regulations to navigate these challenges, ensuring that the pursuit of advanced health care solutions does not compromise patient rights and well-being. This viewpoint aims to ignite a comprehensive dialogue on the responsible integration of digital twins in medicine, advocating for a future where technology serves as a cornerstone for personalized, ethical, and effective patient care.

摘要

数字孪生已成为个性化医疗领域的突破性概念,具有巨大的潜力可以改变医疗保健服务的交付方式并改善患者的治疗效果。需要强调的是,数字孪生在理解患者健康、风险评估、临床试验和药物开发以及患者监测方面对个性化医疗产生的影响。通过镜像个体的健康档案,数字孪生为患者的具体状况提供了无与伦比的深入了解,从而实现更准确的风险评估和针对性的干预措施。然而,它们的应用不仅限于临床获益,还引发了关于数据隐私、同意和医疗保健中潜在偏见的重大伦理辩论。这项技术的快速发展需要在创新和道德责任之间进行谨慎的平衡。随着个性化医疗领域的不断发展,数字孪生在改变医疗保健服务和革新患者护理方面具有巨大的潜力。虽然存在挑战,但数字孪生的持续发展和整合有可能彻底改变个性化医疗,迎来量身定制的治疗和改善患者健康的新时代。数字孪生可以帮助识别可能表明疾病存在或预测特定医疗条件发生可能性以及此类疾病进展的趋势和指标。然而,使用人类数字孪生会引发与知情同意、数据所有权以及基于健康档案的歧视相关的伦理困境。因此,迫切需要制定强有力的指导方针和法规来应对这些挑战,确保在追求先进的医疗保健解决方案时不会损害患者的权利和福祉。这一观点旨在引发关于在医学中负责任地整合数字孪生的全面对话,倡导未来将技术作为个性化、道德和有效的患者护理的基石。

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