Noble Jonathan, Hatter Lee, Eathorne Allie, Hills Thomas, Bean Orlagh, Bruce Pepa, Weatherall Mark, Beasley Richard
Medical Research Institute of New Zealand, Wellington, New Zealand.
Victoria University of Wellington, Wellington, New Zealand.
J Allergy Clin Immunol Glob. 2024 Apr 10;3(3):100258. doi: 10.1016/j.jacig.2024.100258. eCollection 2024 Aug.
In New Zealand a progressive increase in budesonide/formoterol dispensing, accompanied by a reduction in dispensing of short-acting β-agonists (SABAs), inhaled corticosteroids (ICSs), and other ICS/long-acting β-agonists (ICSs/LABAs), occurred in the 18-month period following publication of the 2020 New Zealand asthma guidelines, which recommended budesonide/formoterol anti-inflammatory reliever therapy.
Our aim was to investigate more recent trends in asthma medication use and asthma hospital discharges in New Zealand.
New Zealand national dispensing data for inhalers for the period from January 2010 to December 2022 were reviewed for patients aged 12 years and older. Monthly rates of dispensing of budesonide/formoterol, ICSs, other ICS/LABAs, and SABAs were displayed graphically by locally weighted scatterplot smoother plots. The rates of dispensing and hospital discharge for asthma were compared between the past 6 months for which dispensing data were available (July-December 2022) and the corresponding period from July to December 2019.
There has been a progressive increase in dispensing of budesonide/formoterol since 2019, with a 108% increase between the period from July to December 2019 and the period from July to December 2022 in adolescents and adults. In contrast, there was a reduction in rates of dispensing of other ICS/LABAs, ICSs, and SABAs by 3%, 18%, and 5%, respectively. During this period, there was a 17% reduction in hospital discharges for asthma.
There has been a further widespread uptake of ICS/formoterol reliever and/or maintenance therapy in adolescents and adults with asthma in New Zealand. The changes in prescribing practice have been temporally associated with a reduction in hospital admissions for asthma.
在新西兰,自2020年新西兰哮喘指南发布后的18个月内,布地奈德/福莫特罗的配药量逐渐增加,同时短效β受体激动剂(SABA)、吸入性糖皮质激素(ICS)以及其他ICS/长效β受体激动剂(ICS/LABA)的配药量有所减少。该指南推荐使用布地奈德/福莫特罗进行抗炎缓解治疗。
我们的目的是调查新西兰哮喘药物使用和哮喘住院出院情况的最新趋势。
回顾了2010年1月至2022年12月期间新西兰12岁及以上患者吸入器的全国配药数据。通过局部加权散点图平滑曲线绘制布地奈德/福莫特罗、ICS、其他ICS/LABA和SABA的月配药率。比较了有配药数据的过去6个月(2022年7月至12月)和2019年7月至12月相应期间哮喘的配药率和住院出院率。
自2019年以来,布地奈德/福莫特罗的配药量逐渐增加,青少年和成年人中2019年7月至12月期间与2022年7月至12月期间相比增加了108%。相比之下,其他ICS/LABA、ICS和SABA的配药率分别下降了3%、18%和5%。在此期间,哮喘住院出院人数减少了17%。
在新西兰,哮喘青少年和成年人中,ICS/福莫特罗缓解和/或维持治疗得到了进一步广泛采用。处方实践的变化在时间上与哮喘住院人数的减少相关。