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linc-ADAIN，一种人类脂肪 lincRNA，通过调节 KLF5 和 IL-8 mRNA 的稳定性来调节脂肪生成。

linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.

机构信息

Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.

出版信息

Cell Rep. 2024 May 28;43(5):114240. doi: 10.1016/j.celrep.2024.114240. Epub 2024 May 14.

DOI:10.1016/j.celrep.2024.114240
PMID:38753486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334222/
Abstract

Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here, we describe the functions of linc-ADAIN (adipose anti-inflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that linc-ADAIN knockdown (KD) increases KLF5 and interleukin-8 (IL-8) mRNA stability and translation by interacting with IGF2BP2. Upregulation of KLF5 and IL-8, via linc-ADAIN KD, leads to an enhanced adipogenic program and adipose tissue inflammation, mirroring the obese state, in vitro and in vivo. KD of linc-ADAIN in human adipose stromal cell (ASC) hTERT adipocytes implanted into mice increases adipocyte size and macrophage infiltration compared to implanted control adipocytes, mimicking hallmark features of obesity-induced adipose tissue remodeling. linc-ADAIN is an anti-inflammatory lincRNA that limits adipose tissue expansion and lipid storage.

摘要

脂肪组织重塑和功能障碍，其特征为炎症和胰岛素抵抗升高，在肥胖相关 2 型糖尿病（T2D）和心血管疾病的发展中起着核心作用。长链非编码 RNA（lncRNA）是细胞功能的重要调节因子。在这里，我们描述了 linc-ADAIN（脂肪抗炎）的功能，这是一种在肥胖人群的白色脂肪组织中下调的脂肪 lincRNA。我们证明 linc-ADAIN 敲低（KD）通过与 IGF2BP2 相互作用增加 KLF5 和白细胞介素-8（IL-8）mRNA 的稳定性和翻译。通过 linc-ADAIN KD 上调 KLF5 和 IL-8，导致体外和体内的脂肪生成程序和脂肪组织炎症增强，反映了肥胖状态。在植入小鼠的人脂肪基质细胞（ASC）hTERT 脂肪细胞中敲低 linc-ADAIN，与植入的对照脂肪细胞相比，增加了脂肪细胞的大小和巨噬细胞浸润，模拟了肥胖引起的脂肪组织重塑的特征性特征。linc-ADAIN 是一种抗炎 lincRNA，可限制脂肪组织扩张和脂质储存。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/4644063d4954/nihms-2009043-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/fdddcc03d921/nihms-2009043-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/f72e148d1f72/nihms-2009043-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/a0d3e3eac9f4/nihms-2009043-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/d0b4ce5737dd/nihms-2009043-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/926e26e6b811/nihms-2009043-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/4644063d4954/nihms-2009043-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/fdddcc03d921/nihms-2009043-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/e815864a53db/nihms-2009043-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/f72e148d1f72/nihms-2009043-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/a0d3e3eac9f4/nihms-2009043-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/d0b4ce5737dd/nihms-2009043-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/926e26e6b811/nihms-2009043-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a0/11334222/4644063d4954/nihms-2009043-f0008.jpg

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2
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Long non-coding RNAs: definitions, functions, challenges and recommendations.长非编码 RNA：定义、功能、挑战与建议。
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Int J Mol Sci. 2025 Mar 7;26(6):2415. doi: 10.3390/ijms26062415.
Nat Rev Mol Cell Biol. 2023 Jun;24(6):430-447. doi: 10.1038/s41580-022-00566-8. Epub 2023 Jan 3.
4
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest.2023 年的 STRING 数据库：针对任何感兴趣的测序基因组的蛋白质-蛋白质关联网络和功能富集分析。
Nucleic Acids Res. 2023 Jan 6;51(D1):D638-D646. doi: 10.1093/nar/gkac1000.
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