Baird D D, Tyroler H A, Heiss G, Chambless L E, Hames C G
Am J Epidemiol. 1985 Dec;122(6):982-93. doi: 10.1093/oxfordjournals.aje.a114202.
The relationship between menopausal status and total serum cholesterol was examined cross-sectionally in a population of 40- to 54-year-old black and white women of Evans County, Georgia. The relationship differed in blacks and whites as assessed by a significant interaction term in linear regression. Controlling for age, Quetelet index, and smoking status, white postmenopausal women showed an estimated increase in total serum cholesterol of 25 mg/dl (p less than 0.001) compared with premenopausal whites, whereas black postmenopausal women showed no significant increase in total serum cholesterol compared with premenopausal blacks. The authors were unable to attribute the lack of menopausal effect in blacks to selection or measurement bias, nor did confounding or effect modification by obesity or social status negate their findings. Of six other populations in which menopausal influence on total serum cholesterol has been examined, only Pima Indians failed to show a significant increase.
在佐治亚州埃文斯县40至54岁的黑人和白人女性群体中，对绝经状态与血清总胆固醇之间的关系进行了横断面研究。通过线性回归中的一个显著交互项评估，黑人和白人之间的这种关系有所不同。在控制年龄、体重指数和吸烟状况后，与绝经前的白人女性相比，绝经后的白人女性血清总胆固醇估计升高了25mg/dl（p<0.001），而与绝经前的黑人女性相比，绝经后的黑人女性血清总胆固醇没有显著升高。作者无法将黑人中缺乏绝经效应归因于选择或测量偏倚，肥胖或社会地位造成的混杂或效应修正也没有否定他们的研究结果。在其他六个研究过绝经对血清总胆固醇影响的人群中，只有皮马印第安人没有显示出显著升高。
