Rordorf-Adam C, Serban D, Pataki A, Grüninger M
Clin Exp Immunol. 1985 Sep;61(3):509-16.
The concentration of immunoglobulins, anti-ssDNA, anti-dsDNA, anti-TNP antibodies, IgM rheumatoid factor, C3, immune complexes and serum amyloid P component (SAP), in the serum were measured in 68 male and female MRL/lpr/lpr mice, a strain affected with a systemic autoimmune disease. The degree of lymphoproliferation was assessed by the spleen weight. Spontaneous secretion of immunoglobulins and anti dsDNA antibodies were measured in spleen cell cultures. All mice presented age related increases or decreases (C3) in the level of measured parameters. Inflammatory lesions were detected, by light microscopy in the joints of all mice. There was a significant correlation, in both sexes between the serum level of SAP and the severity of the polyarthritis, as assessed by light microscopy. In female mice the levels of anti-dsDNA antibodies, immunoglobulins, either measured in serum or in the spleen compartment, and circulating immune complexes also showed correlation with the activity of the arthritis, but neither of these variables correlated as closely with arthritis scores as did serum SAP.
在68只患有全身性自身免疫疾病的雄性和雌性MRL/lpr/lpr小鼠中，测量了血清中的免疫球蛋白、抗单链DNA、抗双链DNA、抗三硝基苯抗体、IgM类风湿因子、C3、免疫复合物和血清淀粉样蛋白P成分（SAP）的浓度。通过脾脏重量评估淋巴细胞增殖程度。在脾细胞培养物中测量免疫球蛋白和抗双链DNA抗体的自发分泌。所有小鼠所测参数水平均呈现出与年龄相关的增加或减少（C3）。通过光学显微镜在所有小鼠的关节中检测到炎性病变。通过光学显微镜评估，血清SAP水平与多关节炎严重程度在两性中均存在显著相关性。在雌性小鼠中，血清或脾脏中测量的抗双链DNA抗体、免疫球蛋白水平以及循环免疫复合物也与关节炎活动相关，但这些变量与关节炎评分的相关性均不如血清SAP与关节炎评分的相关性紧密。
