Khan Muhammad Zahoor, Khan Adnan, Huang Bingjian, Wei Ren, Kou Xiyan, Wang Xinrui, Chen Wenting, Li Liangliang, Zahoor Muhammad, Wang Changfa
Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 522000, China.
Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 511464, China.
Antioxidants (Basel). 2024 May 13;13(5):597. doi: 10.3390/antiox13050597.
Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses. It poses a significant threat to the physiological function of reproductive cells. Factors such as xenobiotics and heat can worsen this stress, leading to cellular damage and apoptosis, ultimately decreasing reproductive efficiency. The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a crucial role in defending against oxidative stress and protecting reproductive cells via enhancing antioxidant responses. Dysregulation of Nrf2 signaling has been associated with infertility and suboptimal reproductive performance in mammals. Recent advancements in therapeutic interventions have underscored the critical role of Nrf2 in mitigating oxidative damage and restoring the functional integrity of reproductive cells. In this narrative review, we delineate the harmful effects of heat and xenobiotic-induced oxidative stress on reproductive cells and explain how Nrf2 signaling provides protection against these challenges. Recent studies have shown that activating the Nrf2 signaling pathway using various bioactive compounds can ameliorate heat stress and xenobiotic-induced oxidative distress and apoptosis in mammalian reproductive cells. By comprehensively analyzing the existing literature, we propose Nrf2 as a key therapeutic target for mitigating oxidative damage and apoptosis in reproductive cells caused by exposure to xenobiotic exposure and heat stress. Additionally, based on the synthesis of these findings, we discuss the potential of therapies focused on the Nrf2 signaling pathway to improve mammalian reproductive efficiency.
当活性氧（ROS）的产生与机体的抗氧化防御之间失衡时，就会发生氧化应激。它对生殖细胞的生理功能构成重大威胁。诸如外源性物质和热等因素会加剧这种应激，导致细胞损伤和凋亡，最终降低生殖效率。核因子红细胞2相关因子2（Nrf2）信号通路在抵御氧化应激和通过增强抗氧化反应保护生殖细胞方面发挥着关键作用。Nrf2信号失调与哺乳动物的不育和生殖性能欠佳有关。治疗干预的最新进展强调了Nrf2在减轻氧化损伤和恢复生殖细胞功能完整性方面的关键作用。在这篇叙述性综述中，我们阐述了热和外源性物质诱导的氧化应激对生殖细胞的有害影响，并解释了Nrf2信号通路如何抵御这些挑战。最近的研究表明，使用各种生物活性化合物激活Nrf2信号通路可以改善热应激以及外源性物质诱导的哺乳动物生殖细胞氧化应激和凋亡。通过全面分析现有文献，我们提出Nrf2作为减轻因接触外源性物质和热应激而导致的生殖细胞氧化损伤和凋亡的关键治疗靶点。此外，基于这些研究结果的综合分析，我们讨论了专注于Nrf2信号通路的疗法提高哺乳动物生殖效率的潜力。
