Department of Internal Medicine, Jeju National University Hospital, Jeju 63241, Republic of Korea.
Department of Internal Medicine, Jeju National University College of Medicine, Jeju 63241, Republic of Korea.
Viruses. 2024 Apr 29;16(5):700. doi: 10.3390/v16050700.
This study aimed to analyze the correlation between the cycle threshold (Ct) values of severe fever with thrombocytopenia syndrome (SFTS) virus small (S) and middle (M) segments and the SFTS viral load, aiming to estimate the initial viral load and predict prognosis in the early clinical course.
A retrospective study was conducted with confirmed SFTS patients at Jeju National University Hospital (2016-2022). Patients were categorized into non-fatal and fatal groups.
This study included 49 patients with confirmed SFTS (non-fatal group, = 42; fatal group, = 7). A significant negative correlation (-0.783) was observed between the log SFTS viral load and Ct values ( < 0.001). This negative correlation was notably stronger in the fatal group (correlation coefficient -0.940) than in the non-fatal group (correlation coefficient -0.345).
In this study, we established a correlation between SFTS viral load and Ct values for estimating the initial viral load and early predicting prognosis. These results are expected to offer valuable insights for SFTS patient treatment and prognosis prediction.
本研究旨在分析严重发热伴血小板减少综合征（SFTS）病毒小（S）和中（M）片段的循环阈值（Ct）值与 SFTS 病毒载量之间的相关性，以期在早期临床病程中估算初始病毒载量并预测预后。
对济州国立大学医院（2016-2022 年）确诊的 SFTS 患者进行回顾性研究。将患者分为非致死组和致死组。
本研究纳入 49 例确诊的 SFTS 患者（非致死组，n=42；致死组，n=7）。SFTS 病毒载量的对数与 Ct 值之间呈显著负相关（-0.783， < 0.001）。在致死组中（相关系数-0.940），这种负相关明显强于非致死组（相关系数-0.345）。
本研究建立了 SFTS 病毒载量与 Ct 值之间的相关性，可用于估算初始病毒载量和早期预测预后。这些结果有望为 SFTS 患者的治疗和预后预测提供有价值的见解。
