Rosalia Mariella, Rubes Davide, Serra Massimo, Genta Ida, Dorati Rossella, Conti Bice
Department of Drug Science, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Polymers (Basel). 2024 May 15;16(10):1405. doi: 10.3390/polym16101405.
Poly (glycerol sebacate) is a widely studied elastomeric copolymer obtained from the polycondensation of two bioresorbable monomers, glycerol and sebacic acid. Due to its biocompatibility and the possibility to tailor its biodegradability rate and mechanical properties, PGS has gained lots of interest in the last two decades, especially in the soft tissue engineering field. Different synthetic approaches have been proposed, ranging from classic thermal polyesterification and curing to microwave-assisted organic synthesis, UV crosslinking and enzymatic catalysis. Each technique, characterized by its advantages and disadvantages, can be tailored by controlling the crosslinking density, which depends on specific synthetic parameters. In this work, classic and alternative synthetic methods, as well as characterisation and tailoring techniques, are critically reviewed with the aim to provide a valuable tool for the reproducible and customized production of PGS for tissue engineering applications.
聚癸二酸甘油酯是一种经过广泛研究的弹性体共聚物，由两种生物可吸收单体甘油和癸二酸缩聚而成。由于其生物相容性以及能够调整其生物降解速率和机械性能，在过去二十年中，聚癸二酸甘油酯引起了广泛关注，尤其是在软组织工程领域。人们提出了不同的合成方法，从经典的热聚酯化和固化到微波辅助有机合成、紫外线交联和酶催化。每种技术都有其优缺点，可以通过控制交联密度进行调整，而交联密度取决于特定的合成参数。在这项工作中，对经典和替代合成方法以及表征和调整技术进行了批判性综述，旨在为组织工程应用中可重复和定制生产聚癸二酸甘油酯提供有价值的工具。
