Alosaimi Hind M, Alwatban Rshed A, Alshammari Haifa M, Alshammari Ahmed H, Alanazi Shatha S, Alreshidi Meshal A, Alreshidi Abeer A, Alsayed Abrar S, Alfaraj Furat A, Alzayer Kawther A, Alzaher Aymen A, Almutairi Khawla M, Almutairi Manar S, Aljasir Reema H, Alshammari Mohammed K
Department of Pharmacy Services Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh, Kingdom of Saudi Arabia.
Department of Clinical Pharmacy, Northern Border University, Rafha, Kingdom of Saudi Arabia.
J Pharm Policy Pract. 2024 May 22;17(1):2344223. doi: 10.1080/20523211.2024.2344223. eCollection 2024.
Chronic kidney disease (CKD) is a major public health concern in Saudi Arabia. it is pertinent to mention that in the Southwestern region of Saudi Arabia. Hypertension and diabetes mellites are considered the major drivers of CKD. Research has documented worldwide the inappropriate dose adjustments in patients, ranging from 25% to 77%, of drugs requiring dose modifications. Pharmacists are pivotal members of the healthcare team, tasked with addressing issues pertaining to medications. This study aims to unveil pharmacist perspectives on renal dose adjustment in Saudi Arabia an important step in gauging their involvement in promoting healthy behaviours.
A cross-sectional study design was conducted from December 2023 to January 2024 among pharmacists working in diverse healthcare settings, including clinical and hospital pharmacies, retail, and community pharmacies who had direct encounters with patients diagnosed with CKD. A validated questionnaire, the Renal Dose Adjustment-13 (RDQ-13) was used for this study. For comparing the knowledge, attitude, and perception scores of pharmacists statistical tests like One-Way ANOVA, and independent t-test; while for factors influencing the knowledge, attitude, and perception scores a multivariate linear regression was performed. The statistical significance level was set at 0.05.
A total of 379 pharmacists completed the questionnaire, the knowledge score of pharmacists was 22.06 ± 2.81, while the attitude score was 8.56 ± 2.62 and the practice score was 5.75 ± 2.25. The findings of multivariate linear regression analysis indicated a statistically significant positive association between knowledge score and pharmacist's age while for practice score the findings revealed a statistically negative association between working setting and designation of pharmacists.
The pharmacist in Saudi Arabia exhibited a proficient knowledge score of drug dosage adjustment pertinent to renal function while the attitude and practice score was less as compared to the knowledge score.
慢性肾脏病（CKD）是沙特阿拉伯的一个主要公共卫生问题。值得一提的是，在沙特阿拉伯的西南部地区，高血压和糖尿病被认为是CKD的主要驱动因素。全球研究表明，需要调整剂量的患者中，有25%至77%的药物剂量调整不当。药剂师是医疗团队的关键成员，负责处理与药物相关的问题。本研究旨在揭示沙特阿拉伯药剂师对肾脏剂量调整的看法，这是衡量他们在促进健康行为方面参与程度的重要一步。
2023年12月至2024年1月，对在不同医疗环境中工作的药剂师进行了横断面研究设计，这些医疗环境包括临床和医院药房、零售药房和社区药房，他们直接接触被诊断为CKD的患者。本研究使用了经过验证的问卷《肾脏剂量调整-13》（RDQ-13）。为了比较药剂师的知识、态度和认知得分，采用了单向方差分析和独立t检验等统计测试；而对于影响知识、态度和认知得分的因素，则进行了多元线性回归分析。统计显著性水平设定为0.05。
共有379名药剂师完成了问卷，药剂师的知识得分为22.06±2.81，态度得分为8.56±2.62，实践得分为5.75±2.25。多元线性回归分析结果表明，知识得分与药剂师年龄之间存在统计学上显著的正相关，而对于实践得分，研究结果显示工作环境与药剂师职称之间存在统计学上的负相关。
沙特阿拉伯的药剂师在与肾功能相关的药物剂量调整方面表现出较高的知识得分，但与知识得分相比，态度和实践得分较低。
