Wang Xiaoqin, Wang Caihua, Han Wenjin, Ma Congmin, Sun Jiaru, Wang Tianmeng, Hui Zhaozhao, Lei Shuangyan, Wang Ronghua
Department of Pediatrics, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
School of Nursing, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Front Oncol. 2024 May 10;14:1374743. doi: 10.3389/fonc.2024.1374743. eCollection 2024.
Gastric cancer (GC) imposes a heavy burden on global public health, and microRNAs (miRNAs) play a crucial role in the diagnosis and treatment of GC. Therefore, it is necessary to clarify the hotspots and frontiers in the field of miRNAs in GC to guide future research. A total of 2,051 publications related to miRNAs in GC from January 2013 to December 2023 were searched from the Web of Science Core Collection database. CiteSpace was used to identify research hotspots and delineate developmental trends. In the past decade, China, Nanjing Medical University, and Ba Yi were the most contributing research country, institute, and author in this field, respectively. The role of miRNAs as biomarkers in GC, the mechanism of miRNAs in the progression of GC, and the impact of the mutual effects between miRNAs and on GC have been regarded as the research hotspots. The mechanisms of miRNAs on glucose metabolism and the application of the roles of circular RNAs as miRNA sponges in GC treatment will likely be frontiers. Overall, this study called for strengthened cooperation to identify targets and therapeutic regimes for local specificity and high-risk GC types, and to promote the translation of research results into clinical practice.
胃癌（GC）给全球公共卫生带来了沉重负担，而微小RNA（miRNA）在胃癌的诊断和治疗中起着关键作用。因此，有必要厘清胃癌领域中miRNA的研究热点和前沿，以指导未来研究。从Web of Science核心合集数据库中检索了2013年1月至2023年12月期间与胃癌中miRNA相关的2051篇出版物。使用CiteSpace来识别研究热点并描绘发展趋势。在过去十年中，中国、南京医科大学和巴一分别是该领域贡献最大的研究国家、机构和作者。miRNA作为胃癌生物标志物的作用、miRNA在胃癌进展中的机制以及miRNA与[此处原文缺失部分内容]之间相互作用对胃癌的影响被视为研究热点。miRNA对葡萄糖代谢的机制以及环状RNA作为miRNA海绵在胃癌治疗中的作用应用可能成为前沿领域。总体而言，本研究呼吁加强合作，以确定针对局部特异性和高危胃癌类型的靶点和治疗方案，并促进研究成果转化为临床实践。
