Kimura S, Lewis R V, Stern A S, Rossier J, Stein S, Udenfriend S
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1681-5. doi: 10.1073/pnas.77.3.1681.
Adrenal chromaffin granules contain at least 10 peptides, ranging in size from 3 to 5 kilodaltons, that yield, upon digestion with trypsin, peptides that show specific binding to opiate receptors. All are distinctly different from beta-endorphin. Two of these peptides have been purified to homogeneity and subjected to chemical analysis. One is apparently a [Met]enkephalin precursor containing two copies of the [Met]enkephalin sequence. The other peptide contains both [Leu]enkephalin and [Met]enkephalin sequences and is presumably a common precursor of the two forms of enkephalin.
肾上腺嗜铬颗粒含有至少10种肽，大小从3至5千道尔顿不等，用胰蛋白酶消化后可产生与阿片受体有特异性结合的肽。所有这些肽都与β-内啡肽明显不同。其中两种肽已被纯化至同质并进行了化学分析。一种显然是含有两个[甲硫氨酸]脑啡肽序列拷贝的[甲硫氨酸]脑啡肽前体。另一种肽同时含有[亮氨酸]脑啡肽和[甲硫氨酸]脑啡肽序列，推测是这两种脑啡肽形式的共同前体。
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