Sun Biyang, Wang Peilin, Liang Zihui, Li Zhenrun, Ma Qiang
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Talanta. 2024 Sep 1;277:126343. doi: 10.1016/j.talanta.2024.126343. Epub 2024 May 31.
The van der Waals heterojunction is able to combine the advantages of different materials and has potential to be used in biosensing researches. In this study, we developed a novel van der Waals heterojunction by combining MXene and MoS nanosheets for the electrochemiluminescence (ECL) sensing applications. This van der Waals heterojunction material not only possessed the superior conductivity of MXene, but also regulated the electron transport. Additionally, the incorporation of MoS nanosheets into the MXene interlayers significantly enhances the material stability. Meanwhile, nitrogen-rich quantum dots (N dots) were synthesized as ECL tags with an impressive nitrogen content of up to 75 %. By integrating the ECL response of N dots within the van der Waals heterojunction, we established a highly efficient sensing system for miRNA-373, which overexpressed in triple negative breast cancer tissues. The van der Waals heterojunction-based biosensor can enhance the ECL signal of N dots effectively to detect miRNA-373 from 1 fM to 1 μM. Consequently, the developed sensing system holds promise for the early detection of metastasis of the triple-negative breast cancer, paving the way for the effective clinical interventions.
范德华异质结能够结合不同材料的优点，具有用于生物传感研究的潜力。在本研究中，我们通过将MXene和MoS纳米片结合开发了一种新型范德华异质结用于电化学发光（ECL）传感应用。这种范德华异质结材料不仅具有MXene的优异导电性，还能调节电子传输。此外，将MoS纳米片掺入MXene中间层显著提高了材料稳定性。同时，合成了富含氮的量子点（N点）作为ECL标签，其氮含量高达75%，令人印象深刻。通过整合范德华异质结内N点的ECL响应,我们建立了一种用于检测三阴性乳腺癌组织中过表达的miRNA-373的高效传感系统。基于范德华异质结的生物传感器能够有效增强N点的ECL信号，以检测1 fM至1 μM的miRNA-373。因此，所开发的传感系统有望用于三阴性乳腺癌转移的早期检测，为有效的临床干预铺平道路。
