MXene-Derived Quantum Dot@Gold Nanobones Heterostructure-Based Electrochemiluminescence Sensor for Triple-Negative Breast Cancer Diagnosis.

MXene material has been gradually studied in recent years due to its fascinating characteristics. This work developed a novel MXene-derived quantum dots (MQDs) @gold nanobones (Au NBs) heterostructure as the electrochemiluminescence (ECL) sensor. First, MXene and MQDs were synthesized via the green preparation process, which avoided the harm of hydrofluoric acid to humans and the environment. There was a strong ECL signal enhancement in the MQD@Au NBs heterostructure. On the one hand, Au NBs with surface plasmon resonance (SPR) effect acted as an "electronic regulator" that can transfer electrons to itself to control over-injection of electrons into the conduction band of MQDs. The luminous signal of MQDs can be efficiently generated and significantly amplified in the ECL sensing process. On the other hand, the work function of MQDs with excellent conductivity was relatively close to that of Au NBs in the heterostructure. So, ECL quenching caused by short-distance electron transfer between luminophore and Au nanomaterial has been effectively suppressed. The MQD@Au NBs heterostructure-based ECL sensing system was applied to determine miRNA-26a in the serum of patients with triple-negative breast cancer. It not only provides ideas for the green synthesis of MXene but also provides a guide for the application of MQD@Au NBs heterostructure in the field of ECL sensing.