Department of Biomedicine, Institute of Veterinary Sciences, University of Tiaret, Tiaret, 14000, Algeria.
LEAF-Linking Landscape, Environment, Agriculture and Food Research Center, Associate Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, Lisboa, 1349-017, Portugal.
Trop Anim Health Prod. 2024 Jun 3;56(5):182. doi: 10.1007/s11250-024-04037-4.
Proteomics, the large-scale study of proteins in biological systems has emerged as a pivotal tool in the field of animal and veterinary sciences, mainly for investigating local and rustic breeds. Proteomics provides valuable insights into biological processes underlying animal growth, reproduction, health, and disease. In this review, we highlight the key proteomics technologies, methodologies, and their applications in domestic animals, particularly in the tropical context. We also discuss advances in proteomics research, including integration of multi-omics data, single-cell proteomics, and proteogenomics, all of which are promising for improving animal health, adaptation, welfare, and productivity. However, proteomics research in domestic animals faces challenges, such as sample preparation variation, data quality control, privacy and ethical considerations relating to animal welfare. We also provide recommendations for overcoming these challenges, emphasizing the importance of following best practices in sample preparation, data quality control, and ethical compliance. We therefore aim for this review to harness the full potential of proteomics in advancing our understanding of animal biology and ultimately improve animal health and productivity in local breeds of diverse animal species in a tropical context.
蛋白质组学是在生物系统中大规模研究蛋白质的学科，已成为动物学和兽医学领域的重要工具，主要用于研究本地和乡土品种。蛋白质组学为研究动物生长、繁殖、健康和疾病的生物学过程提供了有价值的见解。在这篇综述中，我们强调了关键的蛋白质组学技术、方法及其在家畜中的应用，特别是在热带环境下的应用。我们还讨论了蛋白质组学研究的进展，包括多组学数据的整合、单细胞蛋白质组学和蛋白质基因组学，所有这些都有望提高动物的健康、适应性、福利和生产力。然而，家畜蛋白质组学研究面临着一些挑战，例如样品制备的变异性、数据质量控制、与动物福利有关的隐私和伦理考虑。我们还提供了克服这些挑战的建议，强调了在样品制备、数据质量控制和伦理合规方面遵循最佳实践的重要性。因此，我们旨在充分利用蛋白质组学的潜力，加深我们对动物生物学的理解，并最终提高热带环境下不同动物品种的本地品种的动物健康和生产力。
