Gürbüzer Nilifer, Özcan Tozoğlu Elif
Department of Psychiatry, Erzurum City Hospital, Erzurum, TUR.
Cureus. 2024 May 2;16(5):e59522. doi: 10.7759/cureus.59522. eCollection 2024 May.
Alcohol Use Disorder (AUD) is a significant public health issue associated with serious health risks. This study aims to reveal the relationship between AUD and inflammatory, immunonutritive, and cardiovascular risk markers by evaluating hemogram and biochemistry parameters together in AUD.
The data of 54 male patients with AUD and 45 male controls were included in the study. Sociodemographic-clinical data of the participants and Alcohol Use Disorders Identification Test (AUDIT) results were obtained from medical records. Systemic immune inflammation index (SII) was obtained with the platelet x neutrophil/lymphocyte formula; systemic immune response index (SIRI) was obtained with the monocyte x neutrophil/lymphocyte formula, plasma atherogenicity index (AIP) was obtained with the ratio of triglyceride to High-density Lipoprotein (HDL) cholesterol. C-Reactive Protein (CRP) albumin-lymphocyte (CALLY) index was obtained with the albumin x lymphocyte/CRP x 10 formula.
Aspartate aminotransferase (AST), Gamma Glutamyl Transferase (GGT) activities, neutrophil, CRP, ferritin, SII, and SIRI levels were significantly higher in those with AUD compared to controls. Laboratory results of those with AUD were consistent with atherogenic dyslipidemia; higher triglyceride and total cholesterol levels and AIP values were found compared to controls. The amount of alcohol consumed was a predictor for high SII, SIRI, and AIP levels. The CALLY index, which evaluates immune function, inflammation, and nutritional status together, was significantly lower in patients compared to controls. The amount of alcohol use and the total AUDIT score were predictors for a low CALLY index.
The results of this study support that AUD is a chronic inflammatory psychiatric disorder. We suggest that new inflammatory, immunonutritive, and cardiovascular biomarkers SII, SIRI, AIP, and CALLY index could be promising clinical tools to evaluate the severity, potential complications, and treatment response of AUD.
酒精使用障碍（AUD）是一个与严重健康风险相关的重大公共卫生问题。本研究旨在通过同时评估AUD患者的血常规和生化参数，揭示AUD与炎症、免疫营养和心血管风险标志物之间的关系。
本研究纳入了54例男性AUD患者和45例男性对照者的数据。参与者的社会人口统计学-临床数据和酒精使用障碍识别测试（AUDIT）结果来自病历。通过血小板×中性粒细胞/淋巴细胞公式计算全身免疫炎症指数（SII）；通过单核细胞×中性粒细胞/淋巴细胞公式计算全身免疫反应指数（SIRI），通过甘油三酯与高密度脂蛋白（HDL）胆固醇的比值计算血浆致动脉粥样硬化指数（AIP）。通过白蛋白×淋巴细胞/CRP×10公式计算C反应蛋白（CRP）-白蛋白-淋巴细胞（CALLY）指数。
与对照组相比，AUD患者的天冬氨酸转氨酶（AST）、γ-谷氨酰转移酶（GGT）活性、中性粒细胞、CRP、铁蛋白、SII和SIRI水平显著更高。AUD患者的实验室结果与致动脉粥样硬化性血脂异常一致；与对照组相比，甘油三酯和总胆固醇水平以及AIP值更高。饮酒量是高SII、SIRI和AIP水平的预测因素。同时评估免疫功能、炎症和营养状况的CALLY指数在患者中显著低于对照组。饮酒量和AUDIT总分是低CALLY指数的预测因素。
本研究结果支持AUD是一种慢性炎症性精神障碍。我们建议，新的炎症、免疫营养和心血管生物标志物SII、SIRI、AIP和CALLY指数可能是评估AUD严重程度、潜在并发症和治疗反应的有前景的临床工具。
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