Department of Pediatrics, Steele Children's Research Center, College of Medicine, University of Arizona Health Sciences, 1501 N. Campbell Avenue, Tucson, AZ, 85724, USA.
Asthma and Airway Disease Research Center, University of Arizona, College of Medicine, University of Arizona Health Sciences, 1501 N. Campbell Avenue, Tucson, AZ, 85724, USA.
Sci Rep. 2024 Jun 4;14(1):12803. doi: 10.1038/s41598-024-63356-6.
We previously reported that asthma prevalence was higher in the United States (US) compared to Mexico (MX) (25.8% vs. 8.4%). This investigation assessed differences in microbial dust composition in relation to demographic and housing characteristics on both sides of the US-MX Border. Forty homes were recruited in the US and MX. Home visits collected floor dust and documented occupants' demographics, asthma prevalence, housing structure, and use characteristics. US households were more likely to have inhabitants who reported asthma when compared with MX households (30% vs. 5%) and had significantly different flooring types. The percentage of households on paved roads, with flushing toilets, with piped water and with air conditioning was higher in the US, while dust load was higher in MX. Significant differences exist between countries in the microbial composition of the floor dust. Dust from Mexican homes was enriched with Alishewanella, Paracoccus, Rheinheimera genera and Intrasporangiaceae family. A predictive metagenomics analysis identified 68 significantly differentially abundant functional pathways between US and MX. This study documented multiple structural, environmental, and demographic differences between homes in the US and MX that may contribute to significantly different microbial composition of dust observed in these two countries.
我们之前报道过，与墨西哥（MX）相比，美国（US）的哮喘患病率更高（25.8%比 8.4%）。本研究评估了与美墨边境两侧人口统计学和住房特征相关的微生物灰尘成分差异。在美国和 MX 招募了 40 户家庭。家庭访问收集了地板灰尘，并记录了居住者的人口统计学、哮喘患病率、住房结构和使用特征。与 MX 家庭相比，美国家庭报告哮喘的居民比例更高（30%比 5%），并且地板类型明显不同。美国家庭中，有更多的家庭居住在铺砌道路上，有冲水厕所，有管道供水和空调，而 MX 家庭的灰尘负荷更高。国家之间地板灰尘的微生物组成存在显著差异。来自墨西哥家庭的灰尘富含 Alishewanella、Paracoccus、Rheinheimera 属和 Intrasporangiaceae 科。预测宏基因组学分析确定了 US 和 MX 之间 68 个功能途径存在显著差异。本研究记录了美国家庭和 MX 家庭之间的多个结构、环境和人口统计学差异，这些差异可能导致这两个国家观察到的灰尘微生物组成存在显著差异。
