Luo Shihong, Lou Fangzhi, Yan Li, Dong Yunmei, Zhang Yingying, Liu Yang, Ji Ping, Jin Xin
College of Stomatology, Chongqing Medical University, Chongqing, China.
Department of Oral Implantology, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, China.
J Oral Microbiol. 2024 Jun 3;16(1):2362313. doi: 10.1080/20002297.2024.2362313. eCollection 2024.
Burning mouth syndrome (BMS) is a chronic idiopathic facial pain with intraoral burning or dysesthesia. BMS patients regularly suffer from anxiety/depression, and the association of psychiatric symptoms with BMS has received considerable attention in recent years. The aims of this study were to investigate the potential interplay between psychiatric symptoms and BMS.
Using 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC/MS) to evaluate the oral microbiota and saliva metabolism of 40 BMS patients [including 29 BMS patients with depression or anxiety symptoms (DBMS)] and 40 age matched healthy control (HC).
The oral microbiota composition in BMS exhibited no significant differences from HC, although DBMS manifested decreased α-diversity relative to HC. Noteworthy was the discernible elevation in the abundance of proinflammatory microorganisms within the oral microbiome of individuals with DBMS. Parallel findings in LC/MS analyses revealed discernible disparities in metabolites between DBMS and HC groups. Principal differential metabolites were notably enriched in amino acid metabolism and lipid metabolism, exhibiting associations with infectious and immunological diseases. Furthermore, the integrated analysis underscores a definitive association between the oral microbiome and metabolism in DBMS.
This study suggests possible future modalities for better understanding the pathogenesis and personalized treatment plans of BMS.
灼口综合征（BMS）是一种伴有口腔内烧灼感或感觉异常的慢性特发性面部疼痛。BMS患者经常患有焦虑/抑郁，近年来，精神症状与BMS的关联受到了相当多的关注。本研究的目的是调查精神症状与BMS之间的潜在相互作用。
使用16S rRNA测序和液相色谱-质谱联用（LC/MS）技术评估40例BMS患者[包括29例伴有抑郁或焦虑症状的BMS患者（DBMS）]和40例年龄匹配的健康对照（HC）的口腔微生物群和唾液代谢情况。
BMS患者的口腔微生物群组成与HC相比无显著差异，尽管DBMS相对于HC表现出α多样性降低。值得注意的是，DBMS个体口腔微生物群中促炎微生物的丰度明显升高。LC/MS分析中的平行发现揭示了DBMS组和HC组之间代谢物的明显差异。主要差异代谢物在氨基酸代谢和脂质代谢中显著富集，与感染性和免疫性疾病有关。此外，综合分析强调了DBMS中口腔微生物群与代谢之间的明确关联。
本研究为更好地理解BMS的发病机制和个性化治疗方案提出了可能的未来模式。
