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肿瘤微环境中肠道菌群与胃癌的相互作用

Interaction between intestinal flora and gastric cancer in tumor microenvironment.

作者信息

Yang Mingjin

机构信息

Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

出版信息

Front Oncol. 2024 May 21;14:1402483. doi: 10.3389/fonc.2024.1402483. eCollection 2024.

DOI:10.3389/fonc.2024.1402483
PMID:38835386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11148328/
Abstract

Gastric Cancer (GC) is a prevalent malignancy globally and is the third leading cause of cancer-related deaths. Recent researches focused on the correlation between intestinal flora and GC. Studies indicate that bacteria can influence the development of gastrointestinal tumors by releasing bacterial extracellular vesicles (BEVs). The Tumor microenvironment (TME) plays an important role in tumor survival, with the interaction between intestinal flora, BEVs, and TME directly impacting tumor progression. Moreover, recent studies have demonstrated that intestinal microflora and BEVs can modify TME to enhance the effectiveness of antitumor drugs. This review article provides an overview and comparison of the biological targets through which the intestinal microbiome regulates TME, laying the groundwork for potential applications in tumor diagnosis, treatment, and prognosis.

摘要

胃癌（GC）是全球范围内一种常见的恶性肿瘤，是癌症相关死亡的第三大主要原因。最近的研究聚焦于肠道菌群与胃癌之间的相关性。研究表明，细菌可通过释放细菌细胞外囊泡（BEVs）影响胃肠道肿瘤的发展。肿瘤微环境（TME）在肿瘤存活中起重要作用，肠道菌群、BEVs和TME之间的相互作用直接影响肿瘤进展。此外，最近的研究表明，肠道微生物群和BEVs可改变TME以提高抗肿瘤药物的疗效。这篇综述文章概述并比较了肠道微生物群调节TME的生物学靶点，为其在肿瘤诊断、治疗和预后方面的潜在应用奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/25b15785c2d4/fonc-14-1402483-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/b56d02df2b8e/fonc-14-1402483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/d493061f873f/fonc-14-1402483-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/25b15785c2d4/fonc-14-1402483-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/b56d02df2b8e/fonc-14-1402483-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/d493061f873f/fonc-14-1402483-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e3d/11148328/25b15785c2d4/fonc-14-1402483-g003.jpg

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Gut Microbes. 2024 Jan-Dec;16(1):2307542. doi: 10.1080/19490976.2024.2307542. Epub 2024 Feb 6.
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The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.细胞外囊泡的蛋白质组学分析揭示了热休克蛋白60在幽门螺杆菌感染中的可能功能。
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