Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, U.K..
Drug Deliv Transl Res. 2024 Aug;14(8):2032-2040. doi: 10.1007/s13346-024-01614-w. Epub 2024 Jun 5.
Drug delivery technology has advanced significantly over >50 years, and has produced remarkable innovation, countless publications and conferences, and generations of talented and creative scientists. However, a critical review of the current state-of-the-art reveals that the translation of clever and sophisticated drug delivery technologies into products, which satisfy important, unmet medical needs and have been approved by the regulatory agencies, has - given the investment made in terms of time and money - been relatively limited. Here, this point of view is illustrated using a case study of technology for drug delivery into and through the skin and aims: to examine the historical development of this field and the current state-of-the-art; to understand why the translation of drug delivery technologies into products that improve clinical outcomes has been quite slow and inefficient; and to suggest how the impact of technology may be increased and the process of concept to approved product accelerated.
药物输送技术在过去的 50 多年里取得了显著的进步，产生了许多创新，无数的出版物和会议，以及一代又一代有才华和创造力的科学家。然而，对当前最先进技术的批判性回顾表明，将巧妙而复杂的药物输送技术转化为满足重要未满足医疗需求并已获得监管机构批准的产品——考虑到在时间和金钱方面的投入——相对有限。在这里，使用药物输送到皮肤和通过皮肤的技术的案例研究来说明这一点，目的是：检查该领域的历史发展和当前的最新技术；了解为什么将药物输送技术转化为改善临床结果的产品的速度如此缓慢且效率低下；并提出如何增加技术的影响力并加速从概念到批准产品的过程。
