Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.
West China School of Medicine, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.
Mol Biomed. 2024 Jun 7;5(1):21. doi: 10.1186/s43556-024-00178-y.
Colorectal carcinoma (CRC) stands as a pressing global health issue, marked by the unbridled proliferation of immature cells influenced by multifaceted internal and external factors. Numerous studies have explored the intricate mechanisms of tumorigenesis in CRC, with a primary emphasis on signaling pathways, particularly those associated with growth factors and chemokines. However, the sheer diversity of molecular targets introduces complexity into the selection of targeted therapies, posing a significant challenge in achieving treatment precision. The quest for an effective CRC treatment is further complicated by the absence of pathological insights into the mutations or alterations occurring in tumor cells. This study reveals the transfer of signaling from the cell membrane to the nucleus, unveiling recent advancements in this crucial cellular process. By shedding light on this novel dimension, the research enhances our understanding of the molecular intricacies underlying CRC, providing a potential avenue for breakthroughs in targeted therapeutic strategies. In addition, the study comprehensively outlines the potential immune responses incited by the aberrant activation of signaling pathways, with a specific focus on immune cells, cytokines, and their collective impact on the dynamic landscape of drug development. This research not only contributes significantly to advancing CRC treatment and molecular medicine but also lays the groundwork for future breakthroughs and clinical trials, fostering optimism for improved outcomes and refined approaches in combating colorectal carcinoma.
结直肠癌（CRC）是一个全球性的健康问题，其特征是不成熟细胞不受控制地增殖，这受到多种内部和外部因素的影响。许多研究已经探讨了结直肠癌的肿瘤发生的复杂机制，主要集中在信号通路，特别是与生长因子和趋化因子相关的信号通路。然而，分子靶点的多样性使得靶向治疗的选择变得复杂，在实现治疗精确性方面带来了重大挑战。由于缺乏对肿瘤细胞中发生的突变或改变的病理见解，有效的 CRC 治疗方法的探索变得更加复杂。这项研究揭示了信号从细胞膜向细胞核的传递，揭示了这一关键细胞过程的最新进展。通过揭示这一新的维度，该研究增强了我们对 CRC 分子复杂性的理解，为靶向治疗策略的突破提供了潜在途径。此外，该研究全面概述了信号通路异常激活引发的潜在免疫反应，特别关注免疫细胞、细胞因子及其对药物开发动态景观的集体影响。这项研究不仅对推进 CRC 治疗和分子医学具有重要意义，也为未来的突破和临床试验奠定了基础，为改善结直肠癌的治疗效果和方法带来了乐观前景。
