Altoukhi Samar M, Zamkah Mariam M, Alharbi Reman A, Alghamdi Shatha K, Aldawsari Lama S, Tarabulsi Muyassar, Rizk Hisham, Sandokji Yousif
College of Medicine.
Departments ofMedical Microbiology and Parasitology.
Ann Med Surg (Lond). 2024 Apr 17;86(6):3478-3486. doi: 10.1097/MS9.0000000000002053. eCollection 2024 Jun.
Diabetic nephropathy is one of the consequences of diabetes mellitus that causes a continuous decline in the eGFR. After the COVID-19 pandemic, studies have shown that patients with diabetic nephropathy who had contracted COVID-19 have higher rates of morbidity and disease progression. The aim of this study was to systematically review the literature to determine and understand the effects and complications of SARS-CoV-2 on patients with diabetic nephropathy.
The authors' research protocol encompassed the study selection process, search strategy, inclusion/exclusion criteria, and a data extraction plan. A systematic review was conducted by a team of five reviewers, with an additional reviewer assigned to address any discrepancies. To ensure comprehensive coverage, the authors employed multiple search engines including PubMed, ResearchGate, ScienceDirect, SDL, Ovid, and Google Scholar.
A total of 14 articles meeting the inclusion criteria revealed that COVID-19 directly affects the kidneys by utilizing ACE2 receptors for cell entry, which is significant because ACE2 receptors are widely expressed in the kidney.
COVID-19 affects kidney health, especially in individuals with diabetic nephropathy. The mechanisms include direct viral infection and immune-mediated injury. Early recognition and management are vital for improving the outcomes.
糖尿病肾病是糖尿病的后果之一，会导致估算肾小球滤过率（eGFR）持续下降。在新冠疫情之后，研究表明感染新冠病毒的糖尿病肾病患者发病率和疾病进展率更高。本研究的目的是系统回顾文献，以确定并了解严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对糖尿病肾病患者的影响及并发症。
作者的研究方案包括研究选择过程、检索策略、纳入/排除标准以及数据提取计划。由五名评审员组成的团队进行了系统回顾，另一名评审员负责处理任何差异。为确保全面覆盖，作者使用了多个搜索引擎，包括PubMed、ResearchGate、ScienceDirect、SDL、Ovid和谷歌学术。
共有14篇符合纳入标准的文章表明，新冠病毒通过利用血管紧张素转换酶2（ACE2）受体进入细胞而直接影响肾脏，这一点很重要，因为ACE2受体在肾脏中广泛表达。
新冠病毒会影响肾脏健康，尤其是糖尿病肾病患者。其机制包括直接病毒感染和免疫介导损伤。早期识别和管理对于改善预后至关重要。
