Department of Radiologic Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Animal House Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia.
PLoS One. 2024 Jun 10;19(6):e0303098. doi: 10.1371/journal.pone.0303098. eCollection 2024.
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the dysfunctional metabolism of carbohydrates, fats, and proteins caused by impaired insulin secretion and insulin resistance. This study investigated the feasibility of using point shear wave elastography (pSWE) of the pancreas by comparing the shear wave velocity (SWV) measurements of three anatomical areas in patients with T1DM and healthy volunteers. This study included 30 patients with T1DM (9 male, 21 female) and 23 healthy controls (11 men, 12 women). Two experienced certified operators performed the examinations and took the SWV measurements. The mean SWV of the entire pancreas parenchyma differed significantly between patients and controls (1.1 ± 0.29 and 0.74 ± 0.19 m/s, respectively; p ≤ 0.001). Moreover, the SWVs of the pancreatic segments were significantly different in patients and controls; the mean SWV values of the pancreas head, body, and tail (respectively) in patients vs. controls were 0.99 ± 0.36 vs. 0.76 ± 0.26 m/s (p = 0.012), 1.1 ± 0.52 vs. 0.74 ± 0.23 (p ≤ 0.001), and 1.0 ± 0.34 vs. 0.73 ± 0.28 (p ≤ 0.001). This study confirmed the feasibility of quantifying pancreas tissue stiffness with pSWE and revealed that patients with T1DM had higher pancreas tissue stiffness than controls. Further studies are required to determine the potential value of pSWE as a screening tool in patients with prediabetes.
1 型糖尿病（T1DM）是一种自身免疫性疾病，其特征是由于胰岛素分泌受损和胰岛素抵抗导致碳水化合物、脂肪和蛋白质代谢功能障碍。本研究通过比较 T1DM 患者和健康志愿者三个解剖区域的剪切波速度（SWV）测量值，探讨了胰腺点剪切波弹性成像（pSWE）的可行性。该研究纳入了 30 例 T1DM 患者（9 名男性，21 名女性）和 23 名健康对照者（11 名男性，12 名女性）。两名经验丰富的认证操作员进行了检查并测量了 SWV。整个胰腺实质的平均 SWV 在患者和对照组之间差异有统计学意义（分别为 1.1±0.29 和 0.74±0.19 m/s；p≤0.001）。此外，胰腺节段的 SWVs 在患者和对照组之间也存在显著差异；患者胰腺头部、体部和尾部的平均 SWV 值（分别）与对照组相比为 0.99±0.36 vs. 0.76±0.26 m/s（p=0.012）、1.1±0.52 vs. 0.74±0.23（p≤0.001）和 1.0±0.34 vs. 0.73±0.28（p≤0.001）。本研究证实了使用 pSWE 定量胰腺组织硬度的可行性，并表明 T1DM 患者的胰腺组织硬度高于对照组。需要进一步的研究来确定 pSWE 作为糖尿病前期患者筛查工具的潜在价值。
