强力霉素对小鼠免疫反应的影响。
Effect of doxycycline on immune response in mice.
作者信息
Bellahsene A, Forsgren A
出版信息
Infect Immun. 1985 May;48(2):556-9. doi: 10.1128/iai.48.2.556-559.1985.
Abstract
The effect of doxycycline on immune response has been studied in mice, cell-mediated immunity being evaluated with the split heart allograft technique. Survival duration of heart transplants in animals treated with 2.5 mg of doxycycline per kg per day from the day of transplantation until rejection was slightly but significantly longer than in untreated animals, 18.8 days (P less than 0.05) as compared with 14.5 days. In doxycycline-treated animals, both agglutinating and hemolytic antibody response to sheep erythrocytes was slightly but significantly decreased, though there was no inhibition of splenic production of antibodies to sheep erythrocytes (as measured by the number of plaques of hemolysis detected). The results show the immune response in mice to be only moderately inhibited by doxycycline. The relevance of experiments in mice is also discussed.
摘要
已经在小鼠中研究了强力霉素对免疫反应的影响，采用裂心同种异体移植技术评估细胞介导的免疫。从移植当天起，每天每千克给予2.5毫克强力霉素治疗的动物，心脏移植的存活时间比未治疗的动物略长，但具有显著差异，分别为18.8天（P小于0.05）和14.5天。在接受强力霉素治疗的动物中，对绵羊红细胞的凝集和溶血抗体反应略有下降，但具有显著差异，不过脾脏对绵羊红细胞产生抗体的能力并未受到抑制（通过检测到的溶血空斑数量来衡量）。结果表明，强力霉素仅对小鼠的免疫反应有中度抑制作用。同时还讨论了小鼠实验的相关性。
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本文引用的文献
1
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Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
2
Effect of tetracycline treatment on immunological responses in mice.四环素治疗对小鼠免疫反应的影响。
Clin Exp Immunol. 1980 Mar;39(3):728-32.
3
Effects of oxytetracycline on in vivo proliferation and differentiation of erythroid and lymphoid cells in the rat.土霉素对大鼠体内红系和淋巴系细胞增殖及分化的影响。
Clin Exp Immunol. 1982 Nov;50(2):327-35.
4
The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio).鲤科鱼类的免疫系统。土霉素与鲤鱼（鲤）体液免疫的调节。
Vet Immunol Immunopathol. 1981 Jun;2(3):281-90. doi: 10.1016/0165-2427(81)90029-5.
5
In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracycline.
J Am Acad Dermatol. 1983 Jun;8(6):807-12. doi: 10.1016/s0190-9622(83)80010-3.
6
Antibiotics and granulocytes. Direct and indirect effects on granulocyte chemotaxis.抗生素与粒细胞。对粒细胞趋化性的直接和间接影响。
Acta Pathol Microbiol Scand C. 1981 Aug;89(4):217-21.
7
Influence of tetracyclines on human polymorphonuclear leukocyte function.四环素对人多形核白细胞功能的影响。
Antimicrob Agents Chemother. 1984 Mar;25(3):354-7. doi: 10.1128/AAC.25.3.354.
8
In vitro effects of doxycycline and tetracycline on mitogen stimulated lymphocyte growth.强力霉素和四环素对丝裂原刺激的淋巴细胞生长的体外作用。
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9
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Chemotherapy. 1966;11(2):73-85. doi: 10.1159/000220439.
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