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nth基因的遗传定位，该基因影响大肠杆菌K-12中的核酸内切酶III（胸腺嘧啶二醇-DNA糖基化酶）

Genetic mapping of nth, a gene affecting endonuclease III (thymine glycol-DNA glycosylase) in Escherichia coli K-12.

作者信息

Weiss B, Cunningham R P

出版信息

J Bacteriol. 1985 May;162(2):607-10. doi: 10.1128/jb.162.2.607-610.1985.

DOI:10.1128/jb.162.2.607-610.1985
PMID:3886628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218891/
Abstract

The nth gene of Escherichia coli affects the production of endonuclease III, a glycosylase-endonuclease that attacks DNA damaged by oxidizing agents or by ionizing radiation. An nth insertion mutant and a deletion mutant were studied. nth is located between add and tyrS on the linkage map of E. coli K-12 and was 97% linked to tyrS in a transduction with phage P1.

摘要

大肠杆菌的第n个基因影响内切核酸酶III的产生，内切核酸酶III是一种糖基化酶-内切核酸酶，可攻击被氧化剂或电离辐射损伤的DNA。对一个nth插入突变体和一个缺失突变体进行了研究。nth位于大肠杆菌K-12连锁图谱上的add和tyrS之间，在噬菌体P1转导中与tyrS的连锁率为97%。

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