Liu Yingying, Jin Di, He Tian, Liao Xinyi, Shao Limei, Shi Lei, Liu Ling
Department of Gastroenterology and Hepatology West China Hospital, Sichuan University Chengdu China.
Department of Urology West China Hospital of Sichuan University Chengdu China.
Food Sci Nutr. 2024 Feb 29;12(6):3993-4004. doi: 10.1002/fsn3.4057. eCollection 2024 Jun.
The effect of low-FODMAPs diet on irritable bowel syndrome (IBS) in Western China has not been reported. We aimed to investigate the effect of low-FODMAPs diet on IBS patients in the area and whether low-FODMAPs diet-induced alterations of microbiota could be improved through probiotics. IBS patients were randomized to the control group, low-FODMAPs diet group, probiotics group, or combined group. IBS Symptom Severity Score questionnaire (IBS-SSS) and IBS Quality of Life Score questionnaire (IBS-QOL) were completed at baseline, 2 and 4 weeks to evaluate the severity of symptoms. Fresh feces were collected for analyses of gut microbiota and short-chain fatty acids at baseline and 4 weeks after intervention. Seventy-three patients were included in the per protocol analysis. After intervention, there was significant improvement in IBS-SSS in the low-FODMAPs group (37.5%, 44.2%), probiotics group (51.4%, 62.0%), and combined group (34.1%, 40.4%) at both 2 weeks and 4 weeks, compared with the baseline ( < .05). In the low-FODMAPs group, the abundance of several microbiota (, , etc.) was significantly decreased. Furthermore, after the supplementation of probiotics in the combined group, the abundance of Genus_, , , , , , and was significantly increased, which was associated with the improvements of symptoms score in the correlation analysis. Our study confirmed the effectiveness and safety of short-term low-FODMAPs diet in IBS symptoms based on the Chinese diet in Western China. The combination of low-FODMAPs and probiotics plays a beneficial role in gut microbiota in IBS.
低聚果糖饮食对中国西部肠易激综合征（IBS）的影响尚未见报道。我们旨在研究低聚果糖饮食对该地区IBS患者的影响，以及低聚果糖饮食引起的微生物群改变是否可通过益生菌得到改善。IBS患者被随机分为对照组、低聚果糖饮食组、益生菌组或联合组。在基线、第2周和第4周完成IBS症状严重程度评分问卷（IBS-SSS）和IBS生活质量评分问卷（IBS-QOL），以评估症状的严重程度。在基线和干预后4周收集新鲜粪便，用于分析肠道微生物群和短链脂肪酸。73例患者纳入符合方案分析。干预后，低聚果糖饮食组在第2周和第4周的IBS-SSS均有显著改善（分别为37.5%、44.2%），益生菌组（分别为51.4%、62.0%）和联合组（分别为34.1%、40.4%），与基线相比差异有统计学意义（P<0.05）。在低聚果糖饮食组中，几种微生物群（如……等）的丰度显著降低。此外，联合组补充益生菌后，……属、……、……、……、……、……和……的丰度显著增加，在相关性分析中这与症状评分的改善相关。我们的研究证实了基于中国西部饮食的短期低聚果糖饮食对IBS症状的有效性和安全性。低聚果糖与益生菌联合对IBS患者的肠道微生物群发挥有益作用。
