Martić Ana, Čižmek Lara, Ul'yanovskii Nikolay V, Paradžik Tina, Perković Lucija, Matijević Gabrijela, Vujović Tamara, Baković Marija, Babić Sanja, Kosyakov Dmitry S, Trebše Polonca, Čož-Rakovac Rozelindra
Laboratory for Aquaculture Biotechnology, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.
Center of Excellence for Marine Bioprospecting (BioProCro), Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.
Antioxidants (Basel). 2023 Apr 1;12(4):857. doi: 10.3390/antiox12040857.
The marine environment has a significant impact on life on Earth. Organisms residing in it are vital for the ecosystem but also serve as an inexhaustible source of biologically active compounds. Herein, the biodiversity of two brown seaweeds, and from the Adriatic Sea, was evaluated. The aim of the study was the determination of differences in compound composition while comparing their activities, including antioxidant, antimicrobial, and enzyme inhibition, in connection to human digestion, dermatology, and neurological disorders. Chemical analysis revealed several terpenoids and steroids as dominant molecules, while fucoxanthin was the main identified pigment in both algae. had higher protein, carbohydrate, and pigment content. Omega-6 and omega-3 fatty acids were identified, with the highest amount of dihomo-γ-linolenic acid and α-linolenic acid in Antimicrobial testing revealed a dose-dependent inhibitory activity of methanolic fraction against and . Moderate antioxidant activity was observed for both algae fractions, while the dietary potential was high, especially for the dichloromethane fraction, with inhibition percentages of around 92% for α-amylase and 57% for pancreatic lipase at 0.25 mg/mL. These results suggest that Dictyota species might be a potent source of naturally derived agents for obesity and diabetes.
海洋环境对地球上的生命有着重大影响。生活在其中的生物对生态系统至关重要，同时也是生物活性化合物取之不尽的来源。在此，对来自亚得里亚海的两种褐藻（此处原文缺失两种褐藻具体名称）的生物多样性进行了评估。该研究的目的是在比较它们与人类消化、皮肤病学和神经紊乱相关的活性（包括抗氧化、抗菌和酶抑制活性）时，确定其化合物组成的差异。化学分析表明，几种萜类化合物和类固醇是主要分子，而岩藻黄质是两种藻类中主要鉴定出的色素。（此处原文缺失一种藻类名称）的蛋白质、碳水化合物和色素含量较高。鉴定出了ω-6和ω-3脂肪酸，（此处原文缺失一种藻类名称）中二十二碳六烯酸和α-亚麻酸的含量最高。抗菌测试显示，甲醇提取物对（此处原文缺失两种细菌名称）具有剂量依赖性抑制活性。两种藻类提取物均表现出适度的抗氧化活性，而膳食潜力较高，尤其是（此处原文缺失一种藻类名称）的二氯甲烷提取物，在0.25mg/mL时，对α-淀粉酶的抑制率约为92%，对胰脂肪酶的抑制率为57%。这些结果表明，网胰藻属物种可能是肥胖症和糖尿病天然衍生药物的有力来源。
