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肠道中的亚油酸有助于抵御小鼠感染的保护作用。 （原句中against前少了个词，翻译不太准确，推测可能是某种物质或情况等，完整准确句子翻译会更清晰）

Intestinal linoleic acid contributes to the protective effects of against infection in mice.

作者信息

Jin Tong, Zhang Yingying, Yang Yanpeng, Teng Yue, Yan Chunhong, Shan Zhongguo, Meng Jianghong, Xia Xiaodong

机构信息

State Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University Dalian China.

Department of Food Safety, College of Food Science and Engineering Northwest A&F University Xianyang China.

出版信息

Imeta. 2024 Apr 27;3(3):e196. doi: 10.1002/imt2.196. eCollection 2024 Jun.

DOI:10.1002/imt2.196
PMID:38898984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11183177/
Abstract

pretreatment mitigated infection in mice. improved gut microbiota disturbed by infection and significantly increased the level of intestinal linoleic acid in mice. Linoleic acid strengthened the intestinal epithelial barrier and reduced pathogen translocation partly by regulating NF-κB/MLCK pathway in a GPR40-dependent manner.

摘要

预处理减轻了小鼠的感染。改善了受感染干扰的肠道微生物群，并显著提高了小鼠肠道亚油酸水平。亚油酸通过以GPR40依赖的方式调节NF-κB/MLCK途径，增强了肠道上皮屏障并减少了病原体易位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb64/11183177/04b38462edc6/IMT2-3-e196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb64/11183177/976b2939bfb5/IMT2-3-e196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb64/11183177/04b38462edc6/IMT2-3-e196-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb64/11183177/976b2939bfb5/IMT2-3-e196-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb64/11183177/04b38462edc6/IMT2-3-e196-g001.jpg

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J Adv Res. 2023 Oct;52:89-102. doi: 10.1016/j.jare.2023.03.008. Epub 2023 Mar 28.
3
Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen.
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