Department of Pediatric and Child Health Nursing, School of Nursing, College of Health Science and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
Department of Pediatric and Child Health Nursing, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
PLoS One. 2024 Jun 20;19(6):e0303292. doi: 10.1371/journal.pone.0303292. eCollection 2024.
Children living with HIV/AIDS are particularly vulnerable to under-nutrition. Under-nutrition associated with HIV/AIDS infection increases the rate of morbidity and mortality in children. To reaffirm a future objective, there needs to be evidence regarding the current national burden of under-nutrition and related factors among children infected with HIV. Hence, the objective of this systematic review and meta-analysis was to estimate the pooled prevalence of under-nutrition, and the pooled effect sizes of associated factors among HIV-infected children in Ethiopia.
We searched Ethiopian universities' online libraries, Google, Google Scholar, PubMed, CINAHL, Cochrane Library, and Scopus to find the primary studies for this review. Publication bias was checked through Egger's regression test. Heterogeneity among the included studies was assessed using the I2 test. The data were extracted using Microsoft Excel and exported to STATA Version 14 statistical software. A random effect meta-analysis model was performed to estimate the pooled prevalence of Under-nutrition.
After reviewing 1449 primary studies, 16 articles met the inclusion criteria and were included in the final meta-analysis. The estimated pooled prevalence of stunting, underweight, and wasting among children living with HIV/AIDS was 32.98% (95% CI: 22.47, 43.50), 29.76% (95% CI: 21.87, 37.66), and 21.16% (95% CI: 14.96, 27.35) respectively.
This study showed that under-nutrition among HIV-infected children in Ethiopia was significantly high. Under-nutrition is more common among HIV-infected children with opportunistic infections, child feeding problems, do not adhere to dietary recommendations, and have diarrhea. The national policies and strategies for ART service- provider centers should maximize their emphasis on reducing under-nutrition among HIV-infected children. Based on this finding, we recommend HIV intervention programs to address nutritional assessment and interventions for HIV-infected children.
The protocol has been registered in the PROSPERO database with a registration number of CRD-394170.
感染艾滋病毒的儿童特别容易营养不良。与艾滋病毒感染相关的营养不良会增加儿童发病率和死亡率。为了重申一个未来的目标，需要有证据表明当前艾滋病毒感染儿童营养不良的国家负担和相关因素。因此，本系统评价和荟萃分析的目的是估计埃塞俄比亚感染艾滋病毒儿童营养不良的总患病率，以及相关因素的总效应大小。
我们在埃塞俄比亚各大学的在线图书馆、谷歌、谷歌学术、PubMed、CINAHL、考科蓝图书馆和 Scopus 上搜索了这项研究的原始文献。使用 Egger 回归检验来检查发表偏倚。使用 I²检验评估纳入研究之间的异质性。使用 Microsoft Excel 提取数据，并将其导出到 STATA 版本 14 统计软件中。采用随机效应荟萃分析模型估计营养不良的总患病率。
在审查了 1449 篇原始文献后，有 16 篇文章符合纳入标准，并纳入最终荟萃分析。感染艾滋病毒的儿童中发育迟缓、体重不足和消瘦的估计总患病率分别为 32.98%（95%CI：22.47，43.50）、29.76%（95%CI：21.87，37.66）和 21.16%（95%CI：14.96，27.35）。
这项研究表明，埃塞俄比亚感染艾滋病毒的儿童中营养不良的现象非常严重。患有机会性感染、儿童喂养问题、不遵守饮食建议和腹泻的艾滋病毒感染儿童中，营养不良更为常见。抗逆转录病毒治疗服务提供者中心的国家政策和战略应最大限度地强调减少感染艾滋病毒的儿童的营养不良。根据这一发现，我们建议艾滋病毒干预方案解决艾滋病毒感染儿童的营养评估和干预问题。
该方案已在 PROSPERO 数据库中注册，注册号为 CRD-394170。
