两性霉素B对感染白色念珠菌小鼠的免疫佐剂活性。
Immunoadjuvant activity of amphotericin B as displayed in mice infected with Candida albicans.
作者信息
Bistoni F, Vecchiarelli A, Mazzolla R, Puccetti P, Marconi P, Garaci E
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):625-31. doi: 10.1128/AAC.27.4.625.
Abstract
Mice receiving a single intraperitoneal injection of amphotericin B showed increased resistance to subsequent challenge with either Candida albicans or Staphylococcus aureus. This enhancement of resistance was obvious in terms of both survival criteria and clearance of the intravenously injected organism from different organs. The protective effect of amphotericin B was conditioned by dose, time of drug administration, and size of yeast or bacterial inoculum and was reversed by cyclophosphamide. Effector cells from mice treated with amphotericin B displayed enhanced fungicidal activity in vitro as measured in a short-term 51Cr release assay. Macrophages from intact animals exposed in vitro to amphotericin B also acquired strong candidacidal reactivity.
摘要
接受单次腹腔注射两性霉素B的小鼠对随后白色念珠菌或金黄色葡萄球菌的攻击显示出抵抗力增强。就生存标准和从不同器官清除静脉注射的生物体而言，这种抵抗力的增强是明显的。两性霉素B的保护作用受剂量、给药时间、酵母或细菌接种物大小的影响，并被环磷酰胺逆转。用两性霉素B处理的小鼠的效应细胞在短期51Cr释放试验中测量显示出体外杀菌活性增强。体外暴露于两性霉素B的完整动物的巨噬细胞也获得了强烈的杀念珠菌反应性。
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